Journal article
The effect of non-stroke cardiovascular disease states on risk for cognitive decline and dementia: A systematic and meta-analytic review
Neuropsychology Review, Vol.28(1), pp.1-15
2018
Appears in Thompson Institute Research Collection
Abstract
Cardiovascular disease is associated with increased risk for cognitive decline and dementia, but it is unclear whether this risk varies across disease states or occurs in the absence of symptomatic stroke. To examine the evidence of increased risk for cognitive decline and dementia following non-stroke cardiovascular disease we conducted two independent meta-analyses in accordance with PRISMA guidelines. The first review examined cardiovascular diagnoses (atrial fibrillation, congestive heart failure, periphery artery disease and myocardial infarction) while the second review assessed the impact of atherosclerotic burden (as indicated by degree of stenosis, calcification score, plaque morphology or number of plaques). Studies eligible for review longitudinally assessed risk for clinically significant cognitive decline and/or dementia and excluded stroke and cognitive impairment at baseline. Summary statistics were computed via the inverse variance weighted method, utilising Cox Proportional Hazards data (Hazard Ratios, HR). Both atrial fibrillation (n = 5, HR = 1.26, 95% CI [1.12, 1.43]) and severe atherosclerosis (n = 4, HR = 1.59, 95% CI [1.12, 2.26]) emerged as significant risk factors for cognitive decline and/or dementia. A small set of studies reviewed, insufficient for meta-analysis, examining congestive heart failure, peripheral artery disease and myocardial infarction suggested that these conditions may also be associated with an increased risk of cognitive decline/dementia. In the absence of stroke, patients with atrial fibrillation or generalised atherosclerosis are at heightened risk for cognitive deterioration. Nonetheless, this paper highlights the need for methodologically rigorous and prospective investigation of the relationship between CVD and dementia.
Details
- Title
- The effect of non-stroke cardiovascular disease states on risk for cognitive decline and dementia: A systematic and meta-analytic review
- Authors
- Kayla B Stefanidis (Author) - University of the Sunshine Coast - Faculty of Arts, Business and LawChristopher D Askew (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringKim Greaves (Author) - University of the Sunshine CoastMathew J Summers (Author) - University of the Sunshine Coast - Faculty of Arts, Business and Law
- Publication details
- Neuropsychology Review, Vol.28(1), pp.1-15
- Publisher
- Springer New York LLC
- Date published
- 2018
- DOI
- 10.1007/s11065-017-9359-z
- ISSN
- 1040-7308
- Organisation Unit
- Road Safety Research Collaboration; Faculty of Science, Health, Education and Engineering; School of Health; School of Social Sciences - Legacy; School of Health and Sport Sciences - Legacy; Thompson Institute; School of Health - Psychology; School of Health - Sports & Exercise Science; School of Law and Society; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451269202621
- Output Type
- Journal article
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- Neurosciences
- Psychology, Clinical
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