Files and links (2)
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
The effect of intrinsically photosensitive retinal ganglion cell (ipRGC) stimulation on axial length changes to imposed optical defocus in young adults
Journal of Optometry, Vol.16(1), pp.53-63
2023
PMID: 35589503
Abstract
Purpose:
The intrinsically photosensitive retinal ganglion cells (ipRGCs) regulate pupil size and circadian rhythms. Stimulation of the ipRGCs using short-wavelength blue light causes a sustained pupil constriction known as the post-illumination pupil response (PIPR). Here we examined the effects of ipRGC stimulation on axial length changes to imposed optical defocus in young adults.
Materials and methods:
Nearly emmetropic young participants were given either myopic (+3 D, n = 16) or hyperopic (-3 D, n = 17) defocus in their right eye for 2 h. Before and after defocus, a series of axial length measurements for up to 180 s were performed in the right eye using the IOL Master following exposure to 5 s red (625 nm, 3.74 × 1014 photons/cm2/s) and blue (470 nm, 3.29 × 1014 photons/cm2/s) stimuli. The pupil measurements were collected from the left eye to track the ipRGC activity. The 6 s and 30 s PIPR, early and late area under the curve (AUC), and time to return to baseline were calculated.
Results:
The PIPR with blue light was significantly stronger after 2 h of hyperopic defocus as indicated by a lower 6 and 30 s PIPR and a larger early and late AUC (all p<0.05). Short-wavelength ipRGC stimulation also significantly exaggerated the ocular response to hyperopic defocus, causing a significantly greater increase in axial length than that resulting from the hyperopic defocus alone (p = 0.017). Neither wavelength had any effect on axial length with myopic defocus.
Conclusions:
These findings suggest an interaction between myopiagenic hyperopic defocus and ipRGC signaling.
Details
- Title
- The effect of intrinsically photosensitive retinal ganglion cell (ipRGC) stimulation on axial length changes to imposed optical defocus in young adults
- Authors
- Ranjay Chakraborty (Corresponding Author) - Flinders UniversityMichael J. Collins (Author) - Queensland University of TechnologyHenry Kricancic (Author) - Queensland University of TechnologyBrett Davis (Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyFan Yi (Author) - Queensland University of TechnologyKarthikeyan Baskaran (Author) - Linnaeus University
- Publication details
- Journal of Optometry, Vol.16(1), pp.53-63
- Publisher
- Colegio Nacional de Opticos Optometristas de Espana,Spanish Council of Optometry
- Date published
- 2023
- DOI
- 10.1016/j.optom.2022.04.002
- ISSN
- 1989-1342; 1888-4296
- PMID
- 35589503
- Copyright note
- © 2022 Spanish General Council of Optometry. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Grant note
- This work was supported by the Flinders University College of Nursing and Health Sciences Establishment Grant [01.529.41820]; and the Contact Lens and Visual Optics Laboratory, Queensland University of Technology, Brisbane, Australia.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973592702621
- Output Type
- Journal article
Metrics
52 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Ophthalmology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites