Journal article
The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions
Physiological Reports, Vol.8(9), e14421
2020
Abstract
INTRODUCTION: Aging is associated with impaired cerebrovascular blood flow and function, attributed to reduced vasodilatory capacity of the cerebrovascular network. Older adults may also have an impaired relationship between changes in blood pressure and cerebral blood flow; however, previous reports conflict. This study aimed to compare the blood pressure and cerebral blood flow responses to both repeated and sustained stand-to-sit transitions in young and older adults, and to assess the relationship with cerebrovascular reactivity. METHODS: In 20 young (age: 24±4 years) and 20 older (age: 71±7 years) adults we compared middle cerebral artery flow velocity (MCAv), end-tidal partial pressure of carbon dioxide (PET CO2 ), and blood pressure (mean arterial blood pressure [MAP]) during repeated stand-to-sit (10 s standing and 10 s sitting) and sustained stand-to-sit (3 min standing followed by 2 min sitting) transitions. Cerebrovascular reactivity to changes in carbon dioxide levels was assessed using a repeated breath-hold test. RESULTS: The % change in MCAv per % change in MAP (%∆MCAv/%∆MAP) was higher in the older adults than in the young adults during repeated stand-to-sit transitions. During the sustained protocol the %∆MCAv/%∆MAP response was similar in both age groups. A high %∆MCAv/%∆MAP response during the repeated stand-to-sit protocol was associated with low cerebrovascular reactivity to CO2 (r = -.39; p < .01), which was significantly lower in the older adults. CONCLUSION: These findings suggest that the higher %∆MCAv/%∆MAP during repeated stand-sit transitions was associated with impaired cerebrovascular reactivity. Impairments in endothelial function and vascular stiffness with age may contribute to the altered transient cerebral pressure-flow responses in older adults.
Details
- Title
- The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions
- Authors
- Timo Klein (Corresponding Author) - University of the Sunshine CoastTom G Bailey (Author) - University of the Sunshine CoastPetra Wollseiffen (Author) - German Sport University Cologne, GermanyStefan Schneider (Author) - University of the Sunshine CoastChristopher D Askew (Corresponding Author) - University of the Sunshine Coast
- Publication details
- Physiological Reports, Vol.8(9), e14421
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2020
- DOI
- 10.14814/phy2.14421
- ISSN
- 2051-817X
- Copyright note
- Copyright © 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451100302621
- Output Type
- Journal article
Metrics
4 File views/ downloads
54 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Physiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites