Journal article
The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma
Pigment Cell & Melanoma Research, Vol.26(6), pp.835-844
2013
Abstract
Summary: We conducted a clinical trial to compare the molecular and cellular responses of human melanocytes and keratinocytes in vivo to solar-simulated ultraviolet radiation (SSUVR) in 57 Caucasian participants grouped according to MC1R genotype. We found that, on average, the density of epidermal melanocytes 14 days after exposure to 2 minimal erythemal dose (MED) SSUVR was twofold higher than baseline (unirradiated) skin. However, the change in epidermal melanocyte counts among people carrying germline MC1R variants (97% increase) was significantly less than those with wild-type MC1R (164% increase; P = 0.01). We also found that sunscreen applied to the skin before exposure to 2 MED SSUVR completely blocked the effects of DNA damage, p53 induction, and cellular proliferation in both melanocytes and keratinocytes. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Details
- Title
- The effect of MC1R variants and sunscreen on the response of human melanocytes in vivo to ultraviolet radiation and implications for melanoma
- Authors
- E Hacker (Author) - Queensland University of TechnologyZ Boyce (Author) - Queensland University of TechnologyMichael G Kimlin (Author) - Queensland University of TechnologyL Wockner (Author) - Queensland Institute of Medical ResearchT Pollak (Author) - Queensland University of TechnologyS A Vaartjes (Author) - Queensland University of TechnologyN K Hayward (Author) - Queensland University of TechnologyD C Whiteman (Author) - Queensland University of Technology
- Publication details
- Pigment Cell & Melanoma Research, Vol.26(6), pp.835-844
- Publisher
- Wiley-Blackwell Publishing Inc.
- Date published
- 2013
- DOI
- 10.1111/pcmr.12157
- ISSN
- 1755-1471
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99449502902621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Cell Biology
- Dermatology
- Oncology
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Source: InCites