Journal article
The dose-response relationship between pseudoephedrine ingestion and exercise performance
Journal of Science and Medicine in Sport, Vol.17(5), pp.531-534
2014
PMID: 23988786
Abstract
Objectives: The purpose of the present study was to examine a possible dose-response between pre-exercise pseudoephedrine intake and cycling time trial performance. Methods: Ten trained male endurance cyclists (26.5±6.2 years, 75.1±5.9 kg, 70.6±6.8 ml.kg-1min-1) undertook three cycling time trials in which a fixed amount of work (7 kJ.kg-1 body mass) was completed in the shortest possible time. Sixty minutes before the start of exercise, subjects orally ingested either 2.3 mg.kg-1 or 2.8 mg.kg-1 body mass of pseudoephedrine or a placebo in a randomized and double-blind manner. Venous blood was sampled at baseline, pre- and post-warm up and post-exercise for the analysis of pH and lactate and glucose concentrations; plasma catecholamine and pseudoephedrine concentrations were measured at all times except post-warm up. Results: Cycling time trial performance (∼30 min) was not enhanced by pseudoephedrine ingestion. Plasma pseudoephedrine concentration increased from pre-warm up to post-exercise in both treatment conditions, with the 2.8 mg.kg-1 body mass dose producing the highest concentration at both time points (2.8 mg.kg-1 > 2.3 mg.kg-1 > placebo; p < 0.001). Conclusions: There was large individual variation in plasma pseudoephedrine concentration between subjects following pseudoephedrine administration. A number of factors clearly influence the uptake and appearance of pseudoephedrine in the blood and these are not yet fully understood. Combined with subsequent differences in plasma pseudoephedrine between individuals, this may partially explain the present findings and also the inconsistencies in performance following pseudoephedrine administration in previous studies.
Details
- Title
- The dose-response relationship between pseudoephedrine ingestion and exercise performance
- Authors
- Kellie R Pritchard-Peschek (Author) - University of QueenslandDavid G Jenkins (Author) - University of QueenslandMark A Osborne (Author) - Queensland Academy of SportGary J Slater (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringDennis R Taaffe (Author) - University of Newcastle
- Publication details
- Journal of Science and Medicine in Sport, Vol.17(5), pp.531-534
- Publisher
- Elsevier Australia
- Date published
- 2014
- DOI
- 10.1016/j.jsams.2013.07.015
- ISSN
- 1440-2440
- PMID
- 23988786
- Copyright note
- Copyright © 2014. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health - Nutrition & Dietetics; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99448645602621
- Output Type
- Journal article
Metrics
62 File views/ downloads
737 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Sport Sciences
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites