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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
The crustacean ecdysone cassette: a gatekeeper for molt and metamorphosis
Journal of Steroid Biochemistry and Molecular Biology, Vol.185, pp.172-183
2019
Abstract
Arthropods have long been utilized as models to explore molecular function, and the findings derived from them can be applied throughout metazoa, including as a basis for medical research. This has led to the adoption of many representative insect models beyond Drosophila, as each lends its own unique perspective to questions in endocrinology and genetics. However, non-insect arthropods are yet to be realised for the potential insight they may provide in such studies. The Crustacea are among the most ancient arthropods from which insects descended, comprising a huge variety of life histories and ecological roles. Of the events in a typical crustacean development, metamorphosis is perhaps the most ubiquitous, challenging and highly studied. Despite this, our knowledge of the endocrinology which underpins metamorphosis is rudimentary at best; although several key molecules have been identified and studied in depth, the link between them is quite nebulous and leans heavily on well-explored insect models, which diverged from the Pancrustacea over 450 million years ago. As omics technologies become increasingly accessible, they bring the prospect of explorative molecular research which will allow us to uncover components and pathways unique to crustaceans. This review reconciles known components of crustacean metamorphosis and reflects on our findings in insects to outline a future search space, with focus given to the ecdysone cascade. To expand our knowledge of this ubiquitous endocrine system not only aids in our understanding of crustacean metamorphosis, but also provides a deeper insight into the adaptive capacity of arthropods throughout evolution.
Details
- Title
- The crustacean ecdysone cassette: a gatekeeper for molt and metamorphosis
- Authors
- Cameron J Hyde (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringAbigail Elizur (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringTomer Ventura (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Journal of Steroid Biochemistry and Molecular Biology, Vol.185, pp.172-183
- Publisher
- Pergamon
- Date published
- 2019
- DOI
- 10.1016/j.jsbmb.2018.08.012
- ISSN
- 0960-0760
- Copyright note
- Copyright © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The final version is available at DOI:10.1016/j.jsbmb.2018.08.012
- Organisation Unit
- School of Science and Engineering - Legacy; School of Education and Tertiary Access; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450788202621
- Output Type
- Journal article
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- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
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