The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA

A N Bateson; Robert J Harvey; W Wisden; T A Glencorse; A A Hicks; S P Hunt; E A Barnard; M G Darlison

doi:10.1016/0169-328X(91)90081-8

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The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA

Journal article

Peer reviewed

The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA

A N Bateson, Robert J Harvey, W Wisden, T A Glencorse, A A Hicks, S P Hunt, E A Barnard and M G Darlison

Molecular Brain Research, Vol.9(4), pp.333-339

1991

DOI: https://doi.org/10.1016/0169-328X(91)90081-8

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Abstract

Benzodiazepine pharmacology

cDNA cloning

chicken brain

GABAA receptor

in situ hybridization

receptor subtype

We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABAA receptor α1 subunit, which is extremely homologous to mammalian α1 subunits. The distribution of α1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the α1 subunit may not necessarily be restricted to receptors having BZI pharmacology. © 1991.

Details

Title: The chicken GABAA receptor α1 subunit: cDNA sequence and localization of the corresponding mRNA
Authors: A N Bateson (Author) - MRC Molecular Neurobiology Unit, United Kingdom
Robert J Harvey (Author) - MRC Molecular Neurobiology Unit, United Kingdom
W Wisden (Author) - MRC Molecular Neurobiology Unit, United Kingdom
T A Glencorse (Author) - MRC Molecular Neurobiology Unit, United Kingdom
A A Hicks (Author) - MRC Molecular Neurobiology Unit, United Kingdom
S P Hunt (Author) - MRC Molecular Neurobiology Unit, United Kingdom
E A Barnard (Author) - MRC Molecular Neurobiology Unit, United Kingdom
M G Darlison (Author) - MRC Molecular Neurobiology Unit, United Kingdom
Publication details: Molecular Brain Research, Vol.9(4), pp.333-339
Publisher: Elsevier BV
Date published: 1991
DOI: 10.1016/0169-328X(91)90081-8
ISSN: 0169-328X
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450349102621
Output Type: Journal article

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