The central and peripheral corneal response to short-term hypoxia

Asif Iqbal; Damien Fisher; David Alonso-Caneiro; Michael J Collins; Stephen J Vincent

doi:10.1111/opo.13380

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The central and peripheral corneal response to short-term hypoxia

Journal article

Open access

Peer reviewed

The central and peripheral corneal response to short-term hypoxia

Asif Iqbal, Damien Fisher, David Alonso-Caneiro, Michael J Collins and Stephen J Vincent

Ophthalmic & Physiological Optics, Vol.44(7), pp.1524-1529

2024

DOI: https://doi.org/10.1111/opo.13380

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Abstract

corneal oedema

corneal recovery

hypoxia

limbus

Purpose To quantify the magnitude and recovery of central and limbal corneal oedema induced by short-term unilateral eyelid closure without contact lens wear. Methods The left eye of 10 adults with healthy corneas was patched using a folded eye pad for 30 min. High-resolution optical coherence tomography images (which captured the limbal and central corneal regions simultaneously) were obtained before patching, immediately after eye opening and again at 1, 2, 5, 6, 9, 10, 14 and 15 mins after eyelid opening. Oedema was measured from the limbus (scleral spur) to the central cornea (thinnest corneal location) along the horizontal meridian. Results A greater amount of limbal oedema was noted (mean [SD] 3.84 [1.79] %) compared to the central cornea (2.48 [0.61] %; p = 0.04) after 30 mins of unilateral eyelid closure. Both central and limbal corneal oedema recovered rapidly following eyelid opening, with no significant differences in the rate of corneal recovery between corneal locations (p = 0.90). Conclusions Short-term unilateral eyelid closure resulted in ~55% more relative oedema in the limbal region compared to the central cornea. Rapid recovery of oedema and corneal overshoot (thinning beyond the baseline corneal thickness) was observed within 1–2 min of eyelid opening for both central and peripheral regions.

Details

Title: The central and peripheral corneal response to short-term hypoxia
Authors: Asif Iqbal (Corresponding Author) - Queensland University of Technology
Damien Fisher (Author) - Queensland University of Technology
David Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Michael J Collins (Author) - Queensland University of Technology
Stephen J Vincent (Author) - Queensland University of Technology
Publication details: Ophthalmic & Physiological Optics, Vol.44(7), pp.1524-1529
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2024
DOI: 10.1111/opo.13380
ISSN: 1475-1313; 0275-5408
Copyright note: © 2024 The Author(s). Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Grant note: Asif Iqbal was funded by a QUT Postgraduate Research Award PhD scholarship and a Dorothy Carlborg Research Award from the Cornea and Contact Lens Society of Australia.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 991057798302621
Output Type: Journal article

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