The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

M Kriebel; J Metzger; S Trinks; D Chugh; Robert J Harvey; K Harvey; H Volkmer

doi:10.1074/jbc.M110.212191

Back

The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

Journal article

Open access

Peer reviewed

The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment

M Kriebel, J Metzger, S Trinks, D Chugh, Robert J Harvey, K Harvey and H Volkmer

Journal of Biological Chemistry, Vol.286(27), pp.24385-24393

2011

DOI: https://doi.org/10.1074/jbc.M110.212191

Files and links (2)

pdf

PDF - Published Version2.11 MBDownload View

Published VersionPDF - Published Version Open Access

url

https://doi.org/10.1074/jbc.M110.212191View

Published Version

Abstract

axon

brain

GABA receptors

gene silencing

synapses

FGFR1

axon Initial Segment

gephyrin

neurofascin

Cell adhesion molecules regulate synapse formation and maintenance via transsynaptic contact stabilization involving both extracellular interactions and intracellular postsynaptic scaffold assembly. The cell adhesion molecule neurofascin is localized at the axon initial segment of granular cells in rat dentate gyrus, which is mainly targeted by chandelier cells. Lentiviral shRNA-mediated knockdown of neurofascin in adult rat brain indicates that neurofascin regulates the number and size of postsynaptic gephyrin scaffolds, the number of GABAA receptor clusters as well as presynaptic glutamate decarboxylase-positive terminals at the axon initial segment. By contrast, overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

Details

Title: The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment
Authors: M Kriebel (Author) - Universität Tübingen, Germany
J Metzger (Author) - Universität Tübingen, Germany
S Trinks (Author) - Universität Tübingen, Germany
D Chugh (Author) - Universität Tübingen, Germany
Robert J Harvey (Author) - University College London, United Kingdom
K Harvey (Author) - University College London, United Kingdom
H Volkmer (Author) - Universität Tübingen, Germany
Publication details: Journal of Biological Chemistry, Vol.286(27), pp.24385-24393
Publisher: American Society for Biochemistry and Molecular Biology, Inc.
Date published: 2011
DOI: 10.1074/jbc.M110.212191
ISSN: 0021-9258
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451205202621
Output Type: Journal article

Metrics

18 File views/ downloads

310 Record Views

60 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites