The between-day reliability of fasted circulating irisin concentrations: a cohort study

James E. Newman; Grace L. Rose; Morgan J. Farley; Nicole Flemming; Tina L. Skinner; David G. Jenkins; Christopher D. Askew; Mia A. Schaumberg

doi:10.1139/facets-2024-0040

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The between-day reliability of fasted circulating irisin concentrations: a cohort study

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The between-day reliability of fasted circulating irisin concentrations: a cohort study

James E. Newman, Grace L. Rose, Morgan J. Farley, Nicole Flemming, Tina L. Skinner, David G. Jenkins, Christopher D. Askew and Mia A. Schaumberg

Facets, Vol.10, pp.1-6

2025

DOI: https://doi.org/10.1139/facets-2024-0040

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Abstract

age

between-day

body composition

irisin

reliability

sex

Irisin blood concentrations are investigated in many applied physiology studies, however between-day reliability is required for accurate interpretation, particularly in longitudinal interventions. Between-day reliability of irisin was calculated, and the influence of participant characteristics explored. Venous blood was sampled 24 h apart in 32 rested and fasted healthy adults (males n = 15, 19–80 years). Plasma irisin concentrations were measured using MILLIPLEX® xMAP immunoassay analysis (Merck KGaA, Darmstadt, Germany). Irisin reliability was analysed using coefficient of variation (CV) and intraclass correlation coefficients (ICCs). Regression analysis was used to explore the influence of participant characteristics. Overall, irisin was reliable between days (CV 12.7%, ICC r = 0.963, p < 0.001), with no influence of participant characteristics, when pre-sampling controls (intake, activity) were applied.

Details

Title: The between-day reliability of fasted circulating irisin concentrations: a cohort study
Authors: James E. Newman (Corresponding Author) - University of the Sunshine Coast
Grace L. Rose - University of the Sunshine Coast
Morgan J. Farley - The University of Queensland
Nicole Flemming - Sunshine Coast Hospital and Health Service
Tina L. Skinner - University of the Sunshine Coast
David G. Jenkins - University of the Sunshine Coast
Christopher D. Askew - University of the Sunshine Coast
Mia A. Schaumberg - University of the Sunshine Coast
Publication details: Facets, Vol.10, pp.1-6
Publisher: Canadian Science Publishing
Date published: 2025
DOI: 10.1139/facets-2024-0040
ISSN: 2371-1671
Copyright note: © 2025 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Data Availability: All authors agree to make data used within this manuscript available, upon request.
Organisation Unit: School of Health - Biomedicine; Healthy Ageing Research Cluster; School of Health; Cancer Research Cluster; School of Health - Sports & Exercise Science
Language: English
Record Identifier: 991113850702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Endocrinology & Metabolism