The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence

Lindsey A Hines; Katherine I Morley; John Strang; Arpana Agrawal; Elliot C Nelson; Dixie J Statham; Nicholas G Martin; Michael T Lynskey

doi:10.1111/add.12963

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The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence

Journal article

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The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence

Lindsey A Hines, Katherine I Morley, John Strang, Arpana Agrawal, Elliot C Nelson, Dixie J Statham, Nicholas G Martin and Michael T Lynskey

Addiction, Vol.110(8), pp.1311-1320

2015

DOI: https://doi.org/10.1111/add.12963

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Abstract

cannabis

twin study

transitions

initiation

subsequent use

cannabis dependence

cannabis abuse

Aims: To test whether speed of transition from first use to subsequent use of cannabis is associated with likelihood of later cannabis dependence and other outcomes, and whether transition speed is attributable to genetic or environmental factors. Design: Cross-sectional interview study Setting: Australia Participants: 2239 twins and siblings who reported using cannabis at least twice (mean age at time of survey = 32.0, 95% CI 31.9 - 32.1, range 22-45). Measurements: Time between first and subsequent cannabis use (within 1 week; within 3 months; between 3 months - 12 months; more than 1 year later), later use of cannabis and symptoms of DSM-IV cannabis abuse/dependence. Multinomial regression analyses (comparison group: more than 1 year later) adjusted the association between speed of transition and the outcomes of cannabis daily use, abuse/dependence, and treatment-seeking after controlling for socio-demographic, childhood, mental health, peer and licit drug factors. Twin modelling estimated the proportion of variance in transition speed attributable to genetic (A), common environment (C) and unique environmental (E) factors. Findings: Subsequent use of cannabis within one week of first use was associated with daily use (OR 2.64, 95% CI 1.75 - 3.99), abuse and/or dependence (OR 3.25, 95%CI 2.31 - 4.56) and treatment-seeking for cannabis problems (OR 1.89, 95%CI 1.03 - 3.46). Subsequent use within 3 months was associated with abuse and/or dependence (OR 1.61, 95%CI 1.18 - 2.19). The majority of the variation of the speed of transition was accounted for by unique environment factors (0.75). Conclusions: Rapid transition from initiation to subsequent use of cannabis is associated with increased likelihood of subsequent daily cannabis use and abuse/dependence. This article is protected by copyright. All rights reserved

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Title: The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence
Authors: Lindsey A Hines (Author) - King's College London, United Kingdom
Katherine I Morley (Author) - King's College London, United Kingdom
John Strang (Author) - King's College London, United Kingdom
Arpana Agrawal (Author) - Washington University School of Medicine, United States
Elliot C Nelson (Author) - Washington University School of Medicine, United States
Dixie J Statham (Author) - University of the Sunshine Coast - Faculty of Arts and Business
Nicholas G Martin (Author) - Queensland Institute of Medical Research
Michael T Lynskey (Author) - King's College London, United Kingdom
Publication details: Addiction, Vol.110(8), pp.1311-1320
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2015
DOI: 10.1111/add.12963
ISSN: 0965-2140
Copyright note: Copyright © 2015 Wiley-Blackwell Publishing Ltd. This is the accepted version of the following article: Hines, L. A., Morley, K. I., Strang, J., Agrawal, A., Nelson, E. C., Statham, D., Martin, N. G., and Lynskey, M. T. (2015) The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence. Addiction, 110: 1311-1320. , which has been published in final form at http://dx.doi.org/10.1111/add.12963
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450196002621
Output Type: Journal article

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