Journal article
The association between contrast-enhanced ultrasound and near-infrared spectroscopy-derived measures of calf muscle microvascular responsiveness in older adults
Heart, Lung and Circulation, Vol.30, pp.1726-1733
2021
Abstract
Background and Aim:
Contrast-enhanced ultrasound (CEUS) measures of post-occlusion skeletal muscle microvascular responsiveness demonstrate the microvascular dysfunction associated with ageing and age-related disease. However, the accessibility of CEUS is limited by the need for intravenous administration of ultrasound contrast agents and sophisticated imaging analysis. Alternative methods are required for the broader assessment of microvascular dysfunction in research and clinical settings. Therefore, we aimed to evaluate the level of association and agreement between CEUS and near-infrared spectroscopy (NIRS)-derived measures of post-occlusion skeletal muscle microvascular responsiveness in older adults.
Methods:
During supine rest, participants (n=15, 67±11 years) underwent 5 minutes of thigh cuff-occlusion (200 mmHg). Post-occlusion CEUS measures of calf muscle microvascular responsiveness were made, including time to 95% peak acoustic intensity (TTP95 AI) and the rate of rise (slope AI). Simultaneous measures, including time to 95% peak oxygenated haemoglobin (TTP95 O2Hb) and slope O2Hb, were made using continuous-wave NIRS in the same muscle region.
Results:
There were strong correlations between TTP95 measures derived from CEUS and NIRS (r=0.834, p=<0.001) and the corresponding measures of slope (r=0.735, p=0.004). The limits of agreement demonstrated by Bland Altman plot analyses for CEUS and NIRS-derived measures of TTP95 (-9.67–1.98 s) and slope (-1.29–5.23%. s-1) were smaller than the minimum differences expected in people with microvascular dysfunction.
Conclusions:
The strong correlations and level of agreement in the present study support the use of NIRS as a non-invasive, portable and cost-effective method for assessing post-occlusion skeletal muscle microvascular responsiveness in older adults.
Details
- Title
- The association between contrast-enhanced ultrasound and near-infrared spectroscopy-derived measures of calf muscle microvascular responsiveness in older adults
- Authors
- Grace Young (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyDigby Krastins (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyDavid Chang (Author) - Sunshine Coast Hospital and Health ServiceJeng Lam (Author) - Sunshine Coast Hospital and Health ServiceJing Quah (Author) - Sunshine Coast Hospital and Health ServiceTony Stanton (Author) - Sunshine Coast Hospital and Health ServiceFraser Russell (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyKim Greaves (Author) - University of the Sunshine CoastYuri Kriel (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- Heart, Lung and Circulation, Vol.30, pp.1726-1733
- Publisher
- Elsevier Australia
- Date published
- 2021
- DOI
- 10.1016/j.hlc.2021.07.004
- ISSN
- 1444-2892
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; Faculty of Science, Health, Education and Engineering; Centre for Bioinnovation; School of Nursing, Midwifery and Paramedicine - Legacy; School of Health - Biomedicine; School of Health - Sports & Exercise Science; School of Health and Sport Sciences - Legacy; Centre for Human Factors and Sociotechnical Systems; Cancer Research Cluster
- Language
- English
- Record Identifier
- 99551008502621
- Output Type
- Journal article
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