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The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence2.08 MB
Published VersionCC BY V4.0, Open Access
Journal article
The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence
Scientific Reports, Vol.13, pp.1-11
2023
PMID: 37193731
Abstract
Ultraviolet autofluorescence (UVAF) imaging is used to visualise ocular surface changes due to sunlight exposure and so is considered to be a biomarker for UV damage. The conjunctival and scleral thicknesses of participants with and without ocular surface UVAF were measured to examine the UVAF associated tissue thicknesses. The presence of UVAF on the ocular surface was associated with significant differences in tissue thickness including thinner conjunctival epitheliums and thicker scleras but predominantly thickening of the conjunctival stroma. Participants were also classified into four groups according to the presence and absence of UVAF on both the temporal and nasal conjunctivas. It was noted that for those that had only nasal UVAF, the temporal conjunctival stroma was significantly thicker even without the presence of UVAF. Some participants with temporal UVAF had signs of pinguecula observed with slit lamp examination and some had OCT SLO enface imaging darkening. These findings highlight the potential of techniques other than slit lamp examination, including tissue thickness measurement and UVAF photography, in the detection of early UV-related changes to the ocular surface.
Details
- Title
- The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence
- Authors
- Pryntha Rajasingam (Author) - Queensland University of TechnologyAlyra Shaw (Corresponding Author) - Queensland University of TechnologyBrett Davis (Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyJared Hamwood (Author) - Queensland University of TechnologyMichael Collins (Author) - Queensland University of Technology
- Publication details
- Scientific Reports, Vol.13, pp.1-11
- Publisher
- Nature Publishing Group
- Date published
- 2023
- DOI
- 10.1038/s41598-023-35062-2
- ISSN
- 2045-2322
- PMID
- 37193731
- Copyright note
- © The Author(s) 2023 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creative commons. org/ licenses/ by/4. 0/.
- Data Availability
- The data that support the findings of this study are available from the corresponding author (AS) upon reasonable request.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973592802621
- Output Type
- Journal article
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- Ophthalmology
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