The appearance of a second genotype of Japanese encephalitis virus in the Australasian region

A T Pyke; D T Williams; D J Nisbet; A F Van den Hurk; C T Taylor; C A Johansen; Joanne Macdonald; R A Hall; R J Simmons; R J Mason; J M Lee; S A Ritchie; G A Smith; J S Mackenzie

doi:10.4269/ajtmh.2001.65.747

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The appearance of a second genotype of Japanese encephalitis virus in the Australasian region

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The appearance of a second genotype of Japanese encephalitis virus in the Australasian region

A T Pyke, D T Williams, D J Nisbet, A F Van den Hurk, C T Taylor, C A Johansen, Joanne Macdonald, R A Hall, R J Simmons, R J Mason, …

American Journal of Tropical Medicine and Hygiene, Vol.65(6), pp.747-753

2001

DOI: https://doi.org/10.4269/ajtmh.2001.65.747

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Abstract

Medical and Health Sciences

In mid-January 2000, the reappearance of Japanese encephalitis (JE) virus activity in the Australasian region was first demonstrated by the isolation of JE virus from 3 sentinel pigs on Badu Island in the Torres Strait. Further evidence of JE virus activity was revealed through the isolation of JE virus from Culex gelidus mosquitoes collected on Badu Island and the detection of specific JE virus neutralizing antibodies in 3 pigs from Saint Pauls community on Moa Island. Nucleotide sequencing and phylogenetic analyses of the premembrane and envelope genes were performed which showed that both the pig and mosquito JE virus isolates (TS00 and TS4152, respectively) clustered in genotype I, along with northern Thai, Cambodian, and Korean isolates. All previous Australasian JE virus isolates belong to genotype II, along with Malaysian and Indonesian isolates. Therefore, for the first time, the appearance and transmission of a second genotype of JE virus in the Australasian region has been demonstrated.

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Title: The appearance of a second genotype of Japanese encephalitis virus in the Australasian region
Authors: A T Pyke (Author)
D T Williams (Author)
D J Nisbet (Author)
A F Van den Hurk (Author)
C T Taylor (Author)
C A Johansen (Author)
Joanne Macdonald (Author)
R A Hall (Author)
R J Simmons (Author)
R J Mason (Author)
J M Lee (Author)
S A Ritchie (Author)
G A Smith (Author)
J S Mackenzie (Author)
Publication details: American Journal of Tropical Medicine and Hygiene, Vol.65(6), pp.747-753
Publisher: American Society of Tropical Medicine and Hygiene
Date published: 2001
DOI: 10.4269/ajtmh.2001.65.747
ISSN: 0002-9637; 0002-9637
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450116502621
Output Type: Journal article
Research Statement: false

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