Journal article
The abundance of deleterious polymorphisms in humans
Genetics, Vol.190(4), pp.1579-1583
2012
Abstract
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans. © 2012 by the Genetics Society of America.
Details
- Title
- The abundance of deleterious polymorphisms in humans
- Authors
- Sankar Subramanian (Author) - Griffith University
- Publication details
- Genetics, Vol.190(4), pp.1579-1583
- Publisher
- Genetics Society of America
- Date published
- 2012
- DOI
- 10.1534/genetics.111.137893
- ISSN
- 0016-6731
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451093802621
- Output Type
- Journal article
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- Genetics & Heredity
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