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The Physiological and Clinical Importance of Cardiorespiratory Fitness in People with Abdominal Aortic Aneurysm657.72 kB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
The Physiological and Clinical Importance of Cardiorespiratory Fitness in People with Abdominal Aortic Aneurysm
Experimental Physiology, Vol.107(4), pp.283-298
2022
Abstract
An abdominal aortic aneurysm (AAA) is an abnormal enlargement of the aorta, below the level of the renal arteries, where the aorta diameter increases by >50%. As an aneurysm increases in size, there is a progressive increase in the risk of rupture, which ranges from 25 to 40% for aneurysms >5.5 cm in diameter. People with AAA are also at a heightened risk of cardiovascular events and associated mortality. Cardiorespiratory fitness is impaired in people with AAA and is associated with poor (postoperative) clinical outcomes, including increased length of hospital stay and postoperative mortality after open surgical or endovascular AAA repair. Although cardiorespiratory fitness is a well-recognized prognostic marker of cardiovascular health and mortality, it is not assessed routinely, nor is it included in current clinical practice guidelines for the management of people with AAA. In this review, we discuss the physiological impact of AAA on cardiorespiratory fitness, in addition to the consequences of low cardiorespiratory fitness on clinical outcomes in people with AAA. Finally, we summarize current evidence for the effect of exercise training interventions on cardiorespiratory fitness in people with AAA, including the associated improvements in postoperative mortality, AAA growth and cardiovascular risk. Based on this review, we propose that cardiorespiratory fitness should be considered as part of the routine risk assessment and monitoring of people with AAA and that targeting improvements in cardiorespiratory fitness with exercise training might represent a viable adjunct treatment strategy for reducing postoperative mortality and disease progression.
Details
- Title
- The Physiological and Clinical Importance of Cardiorespiratory Fitness in People with Abdominal Aortic Aneurysm
- Authors
- Maria-Christina Perissiou (Corresponding Author) - University of PortsmouthTom Bailey (Author) - The University of QueenslandZoe Saynor (Author) - University of PortsmouthAnthony Ian Shepherd (Author) - University of PortsmouthAmy Harwood (Author) - Coventry UniversityChristopher D Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
- Publication details
- Experimental Physiology, Vol.107(4), pp.283-298
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2022
- DOI
- 10.1113/EP089710
- ISSN
- 1469-445X; 0958-0670
- Copyright note
- © 2022 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Organisation Unit
- UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99611608802621
- Output Type
- Journal article
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