The LEISURE Study: A Longitudinal Randomized Controlled Trial Protocol for a Multi-Modal Lifestyle Intervention Study to Reduce Dementia Risk in Healthy Older Adults

Ciara Treacy; Jacob M Levenstein; Annelise  Jefferies; Alexandra Metse; Mia Schaumberg; Anthony Villani; Ana Bouças; Daniel Hermens; Jim Lagopoulos; Sophie Andrews

doi:10.3233/JAD-230193

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The LEISURE Study: A Longitudinal Randomized Controlled Trial Protocol for a Multi-Modal Lifestyle Intervention Study to Reduce Dementia Risk in Healthy Older Adults

Journal article

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The LEISURE Study: A Longitudinal Randomized Controlled Trial Protocol for a Multi-Modal Lifestyle Intervention Study to Reduce Dementia Risk in Healthy Older Adults

Ciara Treacy, Jacob M Levenstein, Annelise Jefferies, Alexandra Metse, Mia Schaumberg, Anthony Villani, Ana Bouças, Daniel Hermens, Jim Lagopoulos and Sophie Andrews

Journal of Alzheimer's Disease, Vol.94(2), pp.841-856

2023

DOI: https://doi.org/10.3233/JAD-230193

PMID: 37334601

Appears in Thompson Institute Research Collection

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Abstract

Aging

Alzheimer s disease

biomarkers

individualized medicine

neurobiology

prevention

Healthy Brain Ageing

Thompson Institute Special Collection

UniSC Diversity Area - Life Stages

Dementia is understood to arise from a mixed etiology, enveloping chronic inflammatory and vascular impacts on the brain, driven by a constellation of modifiable risk factors which are largely mediated by lifestyle-related behaviors. These risk factors manifest over a prolonged preclinical period and account for up to 40% of the population attributable risk for dementia, representing viable targets for early interventions aimed at abating disease onset and progression. Here we outline the protocol for a 12-week randomized control trial (RCT) of a multimodal Lifestyle Intervention Study for Dementia Risk Reduction (LEISURE), with longitudinal follow-up at 6-months and 24-months post-intervention. This trial integrates exercise, diet, sleep, and mindfulness to simultaneously target multiple different etiopathogenetic mechanisms and their interplay in a healthy older adult population (aged 50-85 years), and assesses dementia risk reduction as the primary endpoint. The LEISURE study is located in the Sunshine Coast region of Australia, which has one of the nation's highest proportions of adults aged over 50 years (36.4%), and corresponding dementia prevalence. This trial is novel in its inclusion of mindfulness and sleep as multidomain lifestyle targets, and in its comprehensive suite of secondary outcomes (based on psychological, physical health, sleep activity, and cognitive data) as well as exploratory neuroimaging (magnetic resonance imaging and electroencephalography) and molecular biology measures. These measures will provide greater insights into the brain-behavioral underpinnings of dementia prevention, as well as the predictors and impacts of the proposed lifestyle intervention. The LEISURE study was prospectively registered (ACTRN12620000054910) on 19 January 2020.

Details

Title: The LEISURE Study: A Longitudinal Randomized Controlled Trial Protocol for a Multi-Modal Lifestyle Intervention Study to Reduce Dementia Risk in Healthy Older Adults
Authors: Ciara Treacy (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jacob M Levenstein (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Annelise Jefferies (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Alexandra Metse (Author) - University of the Sunshine Coast, Queensland, School of Health - Psychology
Mia Schaumberg (Author) - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
Anthony Villani (Author) - University of the Sunshine Coast, Queensland, School of Health - Nutrition & Dietetics
Ana Bouças (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Daniel Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Sophie Andrews (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Journal of Alzheimer's Disease, Vol.94(2), pp.841-856
Publisher: IOS Press
Date published: 2023
DOI: 10.3233/JAD-230193
ISSN: 1875-8908
PMID: 37334601
Organisation Unit: School of Health - Biomedicine; School of Health - Nutrition & Dietetics; Thompson Institute; Cancer Research Cluster; School of Health - Psychology
Language: English
Record Identifier: 99735295702621
Output Type: Journal article

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Web Of Science research areas: Neurosciences

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