Journal article
The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives
Cancer Epidemiology, Biomarkers & Prevention, Vol.25(2), pp.239-249
2016
PMID: 26677213
Abstract
Exercise and physical activity have been shown to reduce the risk of many common cancers and strongly influence tumor biology. A cause-effect mechanism explaining this relationship is dependent on cellular pathways that can influence tumor growth and are exercise responsive. The insulin-like growth factor (IGF) axis is reported to promote the development and progression of carcinomas through cellular signaling in cancerous tissues. This review summarizes the physiologic basis of the role of the IGF axis in oncology and the influence of exercise on this process. We examined the effects of exercise prescription on the IGF axis in cancer survivors by evaluating the current scope of the literature. The current research demonstrates a remarkable heterogeneity and inconsistency in the responses of the IGF axis to exercise in breast, prostate, and colorectal cancer survivors. Finally, this review presents an in-depth exploration of the physiologic basis and mechanistic underpinnings of the seemingly disparate relationship between exercise and the IGF axis in oncology. Although there is currently insufficient evidence to categorize the effects of exercise prescription on the IGF axis in cancer survivors, the inconsistency of results suggests a multifaceted relationship, the complexities of which are considered in this review.
Details
- Title
- The Influence of Exercise on the Insulin-like Growth Factor Axis in Oncology: Physiological Basis, Current, and Future Perspectives
- Authors
- James L Devin (Author) - University of QueenslandKate A Bolam (Author) - University of QueenslandDavid G Jenkins (Author) - University of QueenslandTina L Skinner (Author) - University of Queensland
- Publication details
- Cancer Epidemiology, Biomarkers & Prevention, Vol.25(2), pp.239-249
- Publisher
- American Association for Cancer Research
- DOI
- 10.1158/1055-9965.epi-15-0406
- ISSN
- 1538-7755
- PMID
- 26677213
- Organisation Unit
- School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99488706802621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Oncology
- Public, Environmental & Occupational Health
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Source: InCites