Journal article
The Epidemiology of Chlamydia trachomatis Organism Load During Genital Infection: A Systematic Review
Journal of Infectious Diseases, Vol.211(10), pp.1628-1645
2015
Abstract
Background. The role of organism load in Chlamydia trachomatis infection is not well understood. We conducted a systematic review to investigate the epidemiology of C. trachomatis organism load in human genital chlamydia infection. Methods. Embase, PubMed, and Medline databases were searched for literature published through August 2014. English-language publications that quantified load in humans were eligible. Participant characteristics and laboratory data were extracted. Results. A total of 737 records were identified, and 29 publications involving 40 883 participants were included. In women, load was highest for cervical swabs and lowest for urine specimens. In men, load was highest for rectal swabs and similar for urethral swabs and urine specimens. Evidence of any association between load and age, serovar, risk of transmission, hormone levels, and concurrent sexually transmitted infections was inconsistent. Eight of 9 culture-based studies found an association between load and signs and symptoms, in contrast with only 3 of 8 nucleic acid amplification test (NAAT)-based studies (P = .03). Conclusion. Chlamydia organism load varies by specimen type and site of sampling, and viable chlamydia organism load may be a more important indicator of severity of infection than total load measured by NAAT.
Details
- Title
- The Epidemiology of Chlamydia trachomatis Organism Load During Genital Infection: A Systematic Review
- Authors
- Lenka A Vodstrcil (Author) - University of MelbourneRuthy McIver (Author) - Sydney Sexual Health CentreWilhelmina M Huston (Author) - Queensland University of TechnologySepehr N Tabrizi (Author) - University of MelbournePeter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringJane S Hocking (Author) - University of Melbourne
- Publication details
- Journal of Infectious Diseases, Vol.211(10), pp.1628-1645
- Publisher
- Oxford University Press
- Date published
- 2015
- DOI
- 10.1093/infdis/jiu670
- ISSN
- 0022-1899
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99449289502621
- Output Type
- Journal article
Metrics
32 File views/ downloads
957 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Microbiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites