Journal article
The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
Brain Imaging and Behavior, Vol.8(2), pp.153-182
2014
Abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).
Details
- Title
- The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
- Authors
- Paul M Thompson (Corresponding Author) - University of Southern CaliforniaJason L Stein - University of California, Los AngelesSarah E Medland - QIMR Berghofer Medical Research InstituteDerrek P HibarAlejandro Arias Vasquez - Radboud University Medical CenterMiguel E Renteria - QIMR Berghofer Medical Research InstituteRoberto Toro - Université Paris DiderotNeda Jahanshad - University of Southern CaliforniaGunter Schumann - King's College LondonBarbara Franke - Radboud University NijmegenMargaret J Wright - The University of QueenslandNicholas G Martin - QIMR Berghofer Medical Research InstituteIngrid Agartz - University of OsloMartin Alda - Dalhousie UniversitySaud Alhusaini - Royal College of Surgeons in IrelandLaura Almasy - Texas Biomedical Research InstituteJorge Almeida - Dalhousie UniversityKathryn I Alpert - Northwestern UniversityNancy C Andreasen - University of IowaOle A Andreassen - University of OsloLiana G Apostolova - University of California, Los AngelesKatja Appel - Universität GreifswaldNicola J Armstrong - The University of SydneyBenjamin Aribisala - University of EdinburghMark E Bastin - University of EdinburghMichael Bauer - University Hospital Carl Gustav CarusCarrie E Bearden - University of California, Los AngelesØrjan Bergmann - University of OsloElisabeth B Binder - Max Planck Institute of PsychiatryJohn Blangero - Texas Biomedical Research InstituteHenry J Bockholt - Advanced Biomedical Informatics Group LLCErlend Bøen, - Oslo University HospitalCatherine Bois - University of EdinburghDorret I Boomsma - VU University AmsterdamTom Booth - University of EdinburghIan J Bowman - University of Southern CaliforniaJanita Bralten - Radboud University Medical CenterRachel M Brouwer - Utrecht UniversityHan G Brunner - Radboud University Medical CenterDavid G Brohawn - Massachusetts General HospitalRandy L Buckner - Massachusetts General HospitalJan Buitelaar - Radboud University NijmegenKazima Bulayeva - Vavilov Institute of General GeneticsJuan R Bustillo - University of New MexicoVince D Calhoun - Georgia State UniversityDara M Cannon - Ollscoil na Gaillimhe – University of GalwayRita M Cantor - University of California, BerkeleyMelanie A Carless - Texas Biomedical Research InstituteXavier Caseras - Cardiff UniversityGianpiero L Cavalleri - Royal College of Surgeons in IrelandM Mallar Chakravarty - Canadian Association of College and University Student ServicesKiki D Chang - Stanford UniversityChristopher Ching - University of Southern CaliforniaAndrea Christoforou - Oslo University HospitalSven Cichon - University of BonnVincent P Clark - University of New MexicoPatricia J Conrod - Centre Hospitalier Universitaire Sainte-JustineGiovanni Coppola - David Geffen School of Medicine at UCLABenedicto Crespo-Facorro - Instituto de Biomedicina de SevillaJoanne E Curran - Texas Biomedical Research InstituteMichael Czisch - Max Planck Institute of PsychiatryIan Deary - University of EdinburghEco J C de Geus - VU University AmsterdamAnouk den Braber - VU University AmsterdamGiuseppe Delvecchio - King's College LondonChantal Depondt - Université Libre de BruxellesLieuwe de Haan - Amsterdam UMC Location Vrije Universiteit AmsterdamGreig I de Zubicaray - Queensland University of TechnologyDanai Dima - University of LondonRali Dimitrova - University of EdinburghSrdjan Djurovic - Oslo University HospitalHongwei Dong - University of Southern CaliforniaGary Donohoe - Trinity College DublinRavindranath Duggirala - Texas Biomedical Research InstituteThomas D Dyer - Texas Biomedical Research InstituteStefan Ehrlich - University Hospital Carl Gustav CarusCarl Johan Ekman - Karolinska InstitutetT Elvsashagen - Oslo University HospitalLouise Emsell - National University of IrelandSusanne Erk - Charité - Universitätsmedizin BerlinThomas Espeseth - University of OsloJesen Fagerness - Massachusetts General HospitalScott Fears - University of California, IrvineIryna Fedko - University of AmsterdamGuillén Fernández - Radboud University Medical CenterSimon E Fisher - Max Planck Institute for PsycholinguisticsSophia Frangou - Icahn School of Medicine at Mount SinaiEva Maria Frey - University of RegensburgThomas Frodl - RWTH Aachen UniversityVincent Frouin - Commissariat à l'Énergie Atomique et aux Énergies AlternativesHugh Garavan - University of VermontSudheer Giddaluru - University of BergenDavid C Glahn - Boston Children's HospitalBeata Godlewska - University of OxfordRita Z Goldstein - Icahn School of Medicine at Mount SinaiRandy L Gollub - Massachusetts General HospitalHans J Grabe - Universität GreifswaldOliver Grimm - Goethe University FrankfurtOliver Gruber - University Hospital HeidelbergTulio Guadalupe - Max Planck Institute for PsycholinguisticsRaquel E Gur - University of PennsylvaniaRuben C Gur - University of PennsylvaniaHarald H H Göring - Texas Biomedical Research InstituteSaskia Hagenaars - University of EdinburghTomas Hajek - Dalhousie UniversityGeoffrey B Hall - McMaster UniversityJeremy Hall - University of EdinburghJohn Hardy - UCL Queen Square Institute of NeurologyCatharina A Hartman - University of GroningenJohanna Hass - Technische Universität DresdenSean N Hatton - The University of SydneyUnn K Haukvik - University of OsloKatrin Hegenscheid - Universität GreifswaldAndreas Heinz - CharitéIan B Hickie - The University of SydneyBeng-Choon Ho - University of IowaDavid Hoehn - Max Planck Institute of PsychiatryPieter J Hoekstra - University of GroningenMarisa Hollinshead - Harvard UniversityAvram J Holmes - Yale UniversityGeorge Homuth - Universität GreifswaldMartine Hoogman - Radboud University Nijmegenl Elliot Hong - University of Maryland, BaltimoreNorbert Hosten - Universität GreifswaldJouke-Jan Hottenga - Vrije Universiteit AmsterdamHilleke E Hulshoff Pol - University Medical Center UtrechtKristy S Hwang - Oakland UniversityClifford R Jack Jr - Mayo ClinicMark Jenkinson - University of OxfordCaroline Johnston - King's College LondonErik G Jonsson - University of OsloRene Sylvain Kahn - Icahn School of Medicine at Mount SinaiDalia Kasperaviciute - UCL Queen Square Institute of NeurologySinead Kelly - Trinity College DublinKim Sungeun - Indiana University IndianapolisPeter Kochunov - University of Maryland, Baltimore CountyLaura Koenders - Amsterdam UMC Location Vrije Universiteit AmsterdamBernd Kramer - University Hospital HeidelbergJohn B J Kwok - UNSW SydneyJim Lagopoulos (Author) - The University of SydneySee article text for complete list of remaining 146 authors (Author)Alzheimer’s Disease Neuroimaging Initiative (Research Group)EPIGEN Consortium (Research Group)IMAGEN Consortium (Research Group)Saguenay Youth Study (SYS) Group (Research Group)
- Publication details
- Brain Imaging and Behavior, Vol.8(2), pp.153-182
- Publisher
- Springer New York LLC
- Date published
- 2014
- DOI
- 10.1007/s11682-013-9269-5
- ISSN
- 1931-7557
- Copyright note
- This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99450063202621
- Output Type
- Journal article
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