Journal article
The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
Brain Imaging and Behavior, Vol.8(2), pp.153-182
2014
Abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).
Details
- Title
- The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
- Authors
- Jim Lagopoulos (Author) - University of Sydney
- Publication details
- Brain Imaging and Behavior, Vol.8(2), pp.153-182
- Publisher
- Springer New York LLC
- Date published
- 2014
- DOI
- 10.1007/s11682-013-9269-5
- ISSN
- 1931-7557; 1931-7557
- Copyright note
- Copyright © The Author(s) 2014. This article is published with open access at Springerlink.com
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450063202621
- Output Type
- Journal article
- Research Statement
- false
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Neuroimaging
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Source: InCites