The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Paul M Thompson; Jason L Stein; Sarah E Medland; Derrek P Hibar; Alejandro Arias Vasquez; Miguel E Renteria; Roberto Toro; Neda Jahanshad; Gunter Schumann; Barbara Franke; See article text for complete listing of authors.; Jim Lagopoulos

doi:10.1007/s11682-013-9269-5

The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Paul M Thompson, Jason L Stein, Sarah E Medland, Derrek P Hibar, Alejandro Arias Vasquez, Miguel E Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, …

Brain Imaging and Behavior, Vol.8(2), pp.153-182

2014

: https://doi.org/10.1007/s11682-013-9269-5

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Medical and Health Sciences

Psychology and Cognitive Sciences

genetics

MRI

GWAS

consortium

meta-analysis

multi-site

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).

: The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
: Paul M Thompson (Corresponding Author) - University of Southern California
Jason L Stein - University of California, Los Angeles
Sarah E Medland - QIMR Berghofer Medical Research Institute
Derrek P Hibar
Alejandro Arias Vasquez - Radboud University Medical Center
Miguel E Renteria - QIMR Berghofer Medical Research Institute
Roberto Toro - Université Paris Diderot
Neda Jahanshad - University of Southern California
Gunter Schumann - King's College London
Barbara Franke - Radboud University Nijmegen
See article text for complete listing of authors. (Author)
Jim Lagopoulos (Author) - The University of Sydney
: Brain Imaging and Behavior, Vol.8(2), pp.153-182
: Springer New York LLC
: 2014
: 10.1007/s11682-013-9269-5
: 1931-7557
: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
: Thompson Institute
: English
: 99450063202621
: Journal article

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esploro.research.conf.research.portal.label.prefix.inciteWOSResearchAreas: Neuroimaging

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