Journal article
The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγ/IL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice
BioMed Research International, Vol.2019, 1395138
2019
Abstract
Background. Anaerobic Clostridial spores (CG) cause significant oncolysis in hypoxic tumour microenvironment and result in tumour regression in both animal models and clinical trials. The immune mediated response plays a critical role in the antitumour effect by the anaerobic spore treatment. Method. Human papillomavirus 16 E6/E7 transformed TC-1 tumour bearing mice were intravenously administered with low (1 × 108 CFU/kg) or high dosage (3 × 108 CFU/kg) of Derivative Clostridial spore (DCG). Results. Intravenous administration of the derivative of Clostridial ghonii (DCG) spores leads to both tumour and systemic inflammatory responses characterized by increased IFNγ/IL-9 secreting T cells in the spleen and the tumour. Low numbers of antigen specific T cells (<20/106 spleen cells) in the spleen of the tumour bearing mice are also detected after intravenous DCG delivery. Interestingly, our results showed that a mixed IL-9/IFNγ secreting T cell response was induced when the tumour bearing mice received a low dose of DCG spore (1 × 108 CFU/kg), while a strong IFNγ response was elicited with a high dosage of DCG spore (3 × 108 CFU/kg). Conclusion. The dosage of DCG spore will determine the types of the DCG induced immune responses.
Details
- Title
- The Dosage of the Derivative of Clostridium Ghonii (DCG) Spores Dictates Whether an IFNγ/IL-9 or a Strong IFNγ Response Is Elicited in TC-1 Tumour Bearing Mice
- Authors
- Guoying Ni (Author) - Guangdong Pharmaceutical University, ChinaYong Wang (Author) - Shandong Xin Wei Biopharma Co, ChinaDavid Good (Author) - Griffith UniversityJianwei Yuan (Author) - Guangdong Pharmaceutical University, ChinaPan Xuan (Author) - Guangdong Pharmaceutical University, ChinaJou Wei (Author) - Queensland HealthXiao Song Liu (Author) - Guangdong Pharmaceutical University, ChinaMing Q Wei (Author) - Griffith University
- Publication details
- BioMed Research International, Vol.2019, 1395138; 10
- Publisher
- Hindawi Publishing Corporation
- Date published
- 2019
- DOI
- 10.1155/2019/1395138
- ISSN
- 2314-6133
- Copyright note
- Copyright © 2019 Guoying Ni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy
- Language
- English
- Record Identifier
- 99450992702621
- Output Type
- Journal article
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