Journal article
The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans
Depression and Anxiety, Vol.26(1), pp.28-33
2009
PMID: 18833581
Abstract
Background: Variations in genes related to the dopaminergic pathway have been implicated in neuropsychiatric disorders such as schizophrenia, substance misuse, Alzheimer's disease and Post Traumatic Stress Disorder (PTSD). A single nucleotide polymorphism (SNP) (957C4T) and a deletion polymorphism (-141delC) in the DRD2 gene and a SNP (Taq1A) in a gene directly downstream of DRD2 have all been implicated in dopamine functioning in the brain. Methods: To test the importance of these three polymorphisms in PTSD susceptibility, a genetic screen was performed in 127 war veterans diagnosed with PTSD and 228 control individuals without a history of PTSD. Results: No significant association was found between PTSD and the Taq1A or-141delC polymorphisms. However, a significant association was observed with PTSD and the 957C4T polymorphism. PTSD individuals were more likely to carry the C allele compared to the controls (P 5 0.021). Conclusions: Our findings suggest that the 957C4T polymorphism in the DRD2 gene is one of the genetic factors for susceptibility to PTSD.
Details
- Title
- The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans
- Authors
- Joanne Voisey (Author) - Queensland University of TechnologyChristopher D Swagell (Author) - Queensland University of TechnologyIan P Hughes (Author) - Queensland University of TechnologyC Phillip Morris (Author) - Queensland University of TechnologyAngela van Daal (Author) - University of California Los AngelesErnest P Noble (Author) - Nambour Selangor Private Hospital (Australia)Burnett Kann (Author) - Royal Brisbane and Women's HospitalKaren A Heslop (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Queensland University of Technology
- Publication details
- Depression and Anxiety, Vol.26(1), pp.28-33; 6
- Publisher
- John Wiley & Sons, Inc.
- Date published
- 2009
- DOI
- 10.1002/da.20517
- ISSN
- 1522-7154; 1062-6417
- PMID
- 18833581
- Copyright note
- Copyright (c) 2009. This is the peer reviewed version of the following article: Voisey, J., Swagell, C.D., Hughes, I.P., Morris, C.P., van Daal, A., Noble, E.P., Kann, B., Heslop, K.A., Young, R.M. and Lawford, B.R. (2009), The DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans. Depress. Anxiety, 26: 28-33. https://doi.org/10.1002/da.20517, which has been published in final form at https://doi.org/10.1002/da.20517. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550999202621
- Output Type
- Journal article
Metrics
62 File views/ downloads
27 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
- Psychology
- Psychology, Clinical
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites