Journal article
The Comparative RNA Web (CRW) Site: An online database of comparative sequence and structure information for ribosomal, intron, and other RNAs
BMC Bioinformatics, Vol.3, 2
2002
Abstract
Background: Comparative analysis of RNA sequences is the basis for the detailed and accurate predictions of RNA structure and the determination of phylogenetic relationships for organisms that span the entire phylogenetic tree. Underlying these accomplishments are very large, well-organized, and processed collections of RNA sequences. This data, starting with the sequences organized into a database management system and aligned to reveal their higher-order structure, and patterns of conservation and variation for organisms that span the phylogenetic tree, has been collected and analyzed. This type of information can be fundamental for and have an influence on the study of phylogenetic relationships, RNA structure, and the melding of these two fields. Results: We have prepared a large web site that disseminates our comparative sequence and structure models and data. The four major types of comparative information and systems available for the three ribosomal RNAs (5S, 16S, and 23S rRNA), transfer RNA (tRNA), and two of the catalytic intron RNAs (group I and group II) are: (1) Current Comparative Structure Models; (2) Nucleotide Frequency and Conservation Information; (3) Sequence and Structure Data; and (4) Data Access Systems. Conclusions: This online RNA sequence and structure information, the result of extensive analysis, interpretation, data collection, and computer program and web development, is accessible at our Comparative RNA Web (CRW) Site [http://www.rna.icmb.utexas.edu] . In the future, more data and information will be added to these existing categories, new categories will be developed, and additional RNAs will be studied and presented at the CRW Site. © 2002 Cannone et al; licensee BioMed Central Ltd.
Details
- Title
- The Comparative RNA Web (CRW) Site: An online database of comparative sequence and structure information for ribosomal, intron, and other RNAs
- Authors
- Jamie J Cannone (Author) - University of Texas at Austin, United StatesSankar Subramanian (Author) - Arizona State University, United StatesMurray N Schnare (Author) - Dalhousie University, CanadaJames R Collett (Author) - University of Texas at Austin, United StatesLisa M D'Souza (Author) - University of Texas at Austin, United StatesY Du (Author) - University of Texas at Austin, United StatesBrian Feng (Author) - University of Texas at Austin, United StatesNan Lin (Author) - University of Texas at Austin, United StatesLakshmi V Madabusi (Author) - University of Texas at Austin, United StatesKirsten M Müller (Author) - University of Texas at Austin, United StatesNupur Pande (Author) - University of Texas at Austin, United StatesZhidi Shang (Author) - University of Texas at Austin, United StatesNan Yu (Author) - University of Texas at Austin, United StatesRobin R Gutell (Author) - University of Texas at Austin, United States
- Publication details
- BMC Bioinformatics, Vol.3, 2; 31
- Publisher
- BioMed Central Ltd.
- Date published
- 2002
- DOI
- 10.1186/1471-2105-3-2
- ISSN
- 1471-2105
- Copyright note
- Copyright © 2002 Cannone et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the article's original URL.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450912002621
- Output Type
- Journal article
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