Journal article
The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome
Journal of Veterinary Internal Medicine, Vol.29(6), pp.1564-1568
2015
Abstract
Background: Canine epileptoid cramping syndrome (CECS) is a paroxysmal movement disorder of Border Terriers (BTs). These dogs might respond to a gluten-free diet. Objectives: The objective of this study was to examine the clinical and serological effect of a gluten-free diet in BTs with CECS. Animals: Six client-owned BTs with clinically confirmed CECS. Methods: Dogs were prospectively recruited that had at least a 6-month history of CECS based on the observed phenomenology (using video) and had exhibited at least 2 separate episodes on different days. Dogs were tested for anti-transglutaminase 2 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies in the serum at presentation, and 3, 6, and 9 months after the introduction of a gluten-free diet. Duodenal biopsies were performed in 1 dog. Results: Serum TG2 IgA titers were increased in 6/6 BTs (P = .006) and AGA IgG titers were increased in 5/6 BTs at presentation compared to those of controls (P = .018). After 9 months, there was clinical and serological improvement in all BTs with CECS strictly adhering to a gluten-free diet (5/5). One dog had persistently increased antibody titers. This dog scavenged horse manure. On the strict introduction of a gluten-free diet this dog also had an improved clinical and serological response. The diet-associated improvement was reversible in 2 dogs on completion of the study, both of which suffered a relapse of CECS on the re-introduction of gluten. Conclusions: Canine epileptoid cramping syndrome in BTs is a gluten-sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten-free diet. © 2015 American College of Veterinary Internal Medicine.
Details
- Title
- The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome
- Authors
- M Lowrie (Author) - Davies Veterinary Specialists, United KingdomO A Garden (Author) - Royal Veterinary College, United KingdomM Hadjivassiliou (Author) - Royal Hallamshire Hospital, United KingdomRobert J Harvey (Author) - University College London, United KingdomD S Sanders (Author) - Davies Veterinary Specialists, United KingdomR Powell (Author) - Powell Torrance Diagnostic ServicesL Garosi (Author) - Davies Veterinary Specialists, United Kingdom
- Publication details
- Journal of Veterinary Internal Medicine, Vol.29(6), pp.1564-1568
- Publisher
- Wiley-Blackwell Publishing Inc.
- Date published
- 2015
- DOI
- 10.1111/jvim.13643
- ISSN
- 0891-6640
- Copyright note
- Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451056702621
- Output Type
- Journal article
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