Journal article
The Chlamydia suis genome exhibits high levels of diversity, plasticity and mobile antibiotic resistance: comparative genomics of a recent livestock cohort shows influence of treatment regimes
Genome Biology and Evolution, Vol.9(3), pp.750-760
2017
Abstract
Chlamydia suis is an endemic pig pathogen, belonging to a fascinating genus of obligate intracellular pathogens. Of particular interest, this is the only chlamydial species to have naturally acquired genes encoding for tetracycline resistance. To date, the distribution and mobility of the Tet-island is not well understood. Our study focused on whole genome sequencing of 29 C. suis isolates from a recent porcine cohort within Switzerland, combined with data from USA tetracycline-resistant isolates. Our findings show that the genome of C. suis is very plastic, with unprecedented diversity, highly affected by recombination and plasmid exchange. A large diversity of isolates circulates within Europe, even within individual Swiss farms, suggesting that C. suis originated around Europe. New World isolates have more restricted diversity and appear to derive from European isolates, indicating that historical strain transfers to the USA have occurred. The architecture of the Tet-island is variable, but the tetA(C) gene is always intact, and recombination has been a major factor in its transmission within C. suis. Selective pressure from tetracycline use within pigs leads to a higher number of Tet-island carrying isolates, which appear to be lost in the absence of such pressure, whereas the loss or gain of the Tet-island from individual strains is not observed. The Tet-island appears to be a recent import into the genome of C. suis, with a possible American origin.
Details
- Title
- The Chlamydia suis genome exhibits high levels of diversity, plasticity and mobile antibiotic resistance: comparative genomics of a recent livestock cohort shows influence of treatment regimes
- Authors
- Helena M B Seth-Smith (Author) - University of Zurich, SwitzerlandSabrina Wanninger (Author) - University of Zurich, SwitzerlandNathan Bachmann (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringHanna Marti (Author) - University of Zurich, SwitzerlandWeihong Qi (Author) - University of Zurich, SwitzerlandManuela Donati (Author) - University of Bologna, ItalyAntonietta di Francesco (Author) - University of Bologna, ItalyAdam Polkinghorne (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringNicole Borel (Author) - University of Zurich, Switzerland
- Publication details
- Genome Biology and Evolution, Vol.9(3), pp.750-760
- Publisher
- Oxford University Press
- Date published
- 2017
- DOI
- 10.1093/gbe/evx043
- ISSN
- 1759-6653; 1759-6653
- Copyright note
- Copyright © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99450340302621
- Output Type
- Journal article
- Research Statement
- false
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