The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

D D Ward; Mathew J Summers; N L Saunders; K Ritchie; J J Summers; J C Vickers

doi:10.1038/tp.2015.82

Back

The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

Journal article

Open access

Peer reviewed

The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

D D Ward, Mathew J Summers, N L Saunders, K Ritchie, J J Summers and J C Vickers

Translational Psychiatry, Vol.5, pp.1-6

2015

DOI: https://doi.org/10.1038/tp.2015.82

Files and links (2)

pdf

PDF - Published Version (Open Access)344.74 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V4.0, Open Access

url

https://doi.org/10.1038/tp.2015.82View

Published Version

Abstract

BDNF

The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in theTasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.

Details

Title: The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
Authors: D D Ward (Author) - University of Tasmania
Mathew J Summers (Author) - University of the Sunshine Coast - Faculty of Arts and Business
N L Saunders (Author) - University of Tasmania
K Ritchie (Author) - Neuroepidemiology of Ageing Research Unit, United Kingdom
J J Summers (Author) - University of Tasmania
J C Vickers (Author) - University of Tasmania
Publication details: Translational Psychiatry, Vol.5, pp.1-6
Publisher: Nature Publishing Group
Date published: 2015
DOI: 10.1038/tp.2015.82
ISSN: 2158-3188
Copyright note: Copyright © 2015 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449350902621
Output Type: Journal article

Metrics

49 File views/ downloads

1295 Record Views

30 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites