The Association between the Abundance of Homozygous Deleterious Variants and the Morbidity of Dog Breeds

Sankar Subramanian; Manoharan Kumar

doi:10.3390/biology13080574

Back

The Association between the Abundance of Homozygous Deleterious Variants and the Morbidity of Dog Breeds

Journal article

Open access

Peer reviewed

The Association between the Abundance of Homozygous Deleterious Variants and the Morbidity of Dog Breeds

Sankar Subramanian and Manoharan Kumar

Biology , Vol.13(8), pp.1-8

2024

DOI: https://doi.org/10.3390/biology13080574

PMCID: PMC11351664

PMID: 39194512

Files and links (1)

pdf

biology-13-00574-v2792.96 kBDownload View

Published Version Open Access CC BY V4.0

Abstract

inbreeding

morbidity

deleterious SNVs

RoH

population bottleneck

small populations

It is well known that highly inbred dogs are more prone to diseases than less inbred or outbred dogs. This is because inbreeding increases the load of recessive deleterious variants. Using the genomes of 392 dogs belonging to 83 breeds, we investigated the association between the abundance of homozygous deleterious variants and dog health. We used the number of non-routine veterinary care events for each breed to assess the level of morbidity. Our results revealed a highly significant positive relationship between the number of homozygous deleterious variants located within the runs of homozygosity (RoH) tracts of the breeds and the level of morbidity. The dog breeds with low morbidity had a mean of 87 deleterious SNVs within the RoH, but those with very high morbidity had 187 SNVs. A highly significant correlation was also observed for the loss-of-function (LoF) SNVs within RoH tracts. The dog breeds that required more veterinary care had 2.3 times more homozygous LoF SNVs than those that required less veterinary care (112 vs. 50). The results of this study could be useful for understanding the disease burden on breed dogs and as a guide for dog breeding programs.

Details

Title: The Association between the Abundance of Homozygous Deleterious Variants and the Morbidity of Dog Breeds
Authors: Sankar Subramanian (Corresponding Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
Manoharan Kumar - James Cook University
Publication details: Biology , Vol.13(8), pp.1-8
Publisher: MDPI AG
Date published: 2024
DOI: 10.3390/biology13080574
ISSN: 2079-7737
PMID: 39194512; PMC11351664
Copyright note: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Data Availability: This present study did not generate any new data and only used the genome data available from public repositories and previous studies.
Grant note: This study was supported by a grant from the University of the Sunshine Coast to S.S.
Organisation Unit: School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 991055298102621
Output Type: Journal article

Metrics

5 File views/ downloads

88 Record Views