The Amphimedon queenslandica genome and the evolution of animal complexity

M Srivastava; O Simakov; J Chapman; B Fahey; M E A Gauthier; T Mitros; G S Richards; C Conaco; M Dacre; U Hellsten; C Larroux; N H Putnam; M Stanke; M Adamska; A Darling; S M Degnan; T H Oakley; D C Plachetzki; Y Zhai; M Adamski; A Calcino; Scott F Cummins; D M Goodstein; C Harris; D J Jackson; S P Leys; S Shu; B J Woodcroft; M Vervoort; K S Kosik; G Manning; B M Degnan; D S Rokhsar

doi:10.1038/nature09201

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The Amphimedon queenslandica genome and the evolution of animal complexity

Journal article

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The Amphimedon queenslandica genome and the evolution of animal complexity

M Srivastava, O Simakov, J Chapman, B Fahey, M E A Gauthier, T Mitros, G S Richards, C Conaco, M Dacre, U Hellsten, …

Nature, Vol.466(7307), pp.720-726

2010

DOI: https://doi.org/10.1038/nature09201

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Abstract

evolution

cancer

developmental biology

Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the Great Barrier Reef, and show that it is remarkably similar to other animal genomes in content, structure and organization. Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes. This diverse 'toolkit' of genes correlates with critical aspects of all metazoan body plans, and comprises cell cycle control and growth, development, somatic- and germ-cell specification, cell adhesion, innate immunity and allorecognition. Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity.

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Title: The Amphimedon queenslandica genome and the evolution of animal complexity
Authors: M Srivastava (Author) - University of California, United States
O Simakov (Author) - University of Heidelberg, Germany
J Chapman (Author) - Department of Energy Joint Genome Institute, United States
B Fahey (Author) - University of Queensland
M E A Gauthier (Author) - University of Queensland
T Mitros (Author) - University of California, United States
G S Richards (Author) - University of Queensland
C Conaco (Author) - University of California Santa Barbara, United States
M Dacre (Author) - Salk Institute for Biological Studies, United States
U Hellsten (Author) - Department of Energy Joint Genome Institute, United States
C Larroux (Author) - University of Queensland
N H Putnam (Author) - Rice University, United States
M Stanke (Author) - Abteilung für Bioinformatik, Germany
M Adamska (Author) - University of Queensland
A Darling (Author) - University of California-Davis, United States
S M Degnan (Author) - University of Queensland
T H Oakley (Author) - University of California Santa Barbara, United States
D C Plachetzki (Author) - University of California Santa Barbara, United States
Y Zhai (Author) - Salk Institute for Biological Studies, United States
M Adamski (Author) - University of Queensland
A Calcino (Author) - University of Queensland
Scott F Cummins (Author) - University of Queensland
D M Goodstein (Author) - Department of Energy Joint Genome Institute, United States
C Harris (Author) - University of Queensland
D J Jackson (Author) - University of Queensland
S P Leys (Author) - University of Alberta, Canada
S Shu (Author) - Department of Energy Joint Genome Institute, United States
B J Woodcroft (Author) - University of Queensland
M Vervoort (Author) - Institut Jacques Monod, France
K S Kosik (Author) - University of California Santa Barbara, United States
G Manning (Author) - Salk Institute for Biological Studies, United States
B M Degnan (Author) - University of Queensland
D S Rokhsar (Author) - University of California, United States
Publication details: Nature, Vol.466(7307), pp.720-726
Publisher: Nature Publishing Group
Date published: 2010
DOI: 10.1038/nature09201
ISSN: 0028-0836
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449344102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology