The A1 allele of the D2 dopamine receptor gene region, alcohol expectancies and drinking refusal self-efficacy are associated with alcohol dependence severity

Jason P Connor; Ross Young; John B Saunders; Bruce R Lawford; Robert Ho; Terry L Ritchie; Ernest P Noble

doi:10.1016/j.psychres.2007.06.030

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The A1 allele of the D2 dopamine receptor gene region, alcohol expectancies and drinking refusal self-efficacy are associated with alcohol dependence severity

Journal article

Peer reviewed

The A1 allele of the D2 dopamine receptor gene region, alcohol expectancies and drinking refusal self-efficacy are associated with alcohol dependence severity

Jason P Connor, Ross Young, John B Saunders, Bruce R Lawford, Robert Ho, Terry L Ritchie and Ernest P Noble

Psychiatry Research, Vol.160(1), pp.94-105

2008

DOI: https://doi.org/10.1016/j.psychres.2007.06.030

PMID: 18514919

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Abstract

Genetics

DRD2

Path analysis

Expectancy

Alcoholism

Psychological risk and genetic risk for alcohol dependence are rarely examined in concert. The current study used path analysis (via structural equation modelling) to explore the relationship between the A(1) allele of the D2 dopamine receptor DRD2 gene region, age of problem drinking onset, alcohol expectancy and drinking refusal self-efficacy towards alcohol consumption and dependence severity. One hundred and forty-three (93 male, 50 female) alcohol dependent inpatients provided an extensive clinical history, including age of onset of problem drinking and quantity and frequency of alcohol consumption. The Drinking Expectancy Profile and the Alcohol Dependence Scale were completed, and 10 milliliters of blood were obtained for genetic analysis. The results showed that the posited model fitted the data set well and support the pattern of direct (allele status to drinking) and indirect (allele status influenced by psychosocial variables) relationships hypothesised for the model. A formal test of mediation showed some support for a psychosocial mediational model. The results are discussed in terms of a possible developmental trajectory that involves both genetic risk that influences brain dopamine activity and reinforcement expectancies that both operate via diminished drinking refusal self-efficacy. The prevention and treatment possibilities that arise from understanding this trajectory are examined.

Details

Title: The A1 allele of the D2 dopamine receptor gene region, alcohol expectancies and drinking refusal self-efficacy are associated with alcohol dependence severity
Authors: Jason P Connor (Author) - University of Queensland
Ross Young (Author) - Queensland University of Technology
John B Saunders (Author) - University of Queensland
Bruce R Lawford (Author) - Royal Brisbane and Women's Hospital
Robert Ho (Author) - Central Queensland University
Terry L Ritchie (Author) - University of California Los Angeles
Ernest P Noble (Author) - University of California Los Angeles
Publication details: Psychiatry Research, Vol.160(1), pp.94-105
Publisher: Elsevier Ireland Ltd.
DOI: 10.1016/j.psychres.2007.06.030
ISSN: 1872-7123
PMID: 18514919
Organisation Unit: Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99551007902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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