Journal article
The A allele of the rs1990760 Polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells
PLoS One, Vol.8(12), e83451
2013
Abstract
Background: The rs1990760 polymorphism of interferon induced with helicase C domain 1 (IFIH1 ) has been associated with type 1 diabetes mellitus (T1DM). Here, we investigated whether this polymorphism is associated with T1DM or its clinical characteristics in a Brazilian population, and if IFIH1 gene expression in mononuclear cells from T1DM patients differs according to the genotypes of this polymorphism. A meta-analysis was also conducted to evaluate if the rs1990760 polymorphism is associated with T1DM. Methods: Frequencies of the rs1990760 polymorphism were analyzed in 527 T1DM patients and in 517 healthy subjects. IFIH1 gene expressions according to genotypes were measured in a sub-sample of 26 T1DM patients by quantitative real-time PCR. Results: Our data show the association of the A allele with risk to T1DM under a dominant model of inheritance [odds ratio (OR) = 1.421, P = 0.037], adjusting for ethnicity. The meta-analysis revealed significant association between the rs199760A allele and risk for T1DM for all analyzed inheritance models. Surprisingly, T1DM patients carrying the A allele showed lower levels of systolic (P = 0.001) and diastolic (P = 1 × 10-10) blood pressures as compared to G/G carriers. Furthermore, the A/A genotype seems to be associated with protection to arterial hypertension (AH) after adjustment for covariates (OR = 0.339, P = 0.019). IFIH1 gene expression in mononuclear cells from 26 T1DM patients did not differ among genotypes (P = 0.274). Nevertheless, IFIH1 gene expression was increased in mononuclear cells from T1DM patients with AH as compared with T1DM patients without AH [6.7 (1.7-2.0) vs. 1.8 (1.3-7.1) arbitrary units; P = 0.036]. The association with blood pressures and AH was not observed in patients with type 2 diabetes mellitus. Conclusions: Our results indicate that the rs1990760 polymorphism is associated with T1DM. Interestingly, the rs1990760 A allele seems to be associated with protection for AH in T1DM patients. Further studies are needed to confirm the association with AH.
Details
- Title
- The A allele of the rs1990760 Polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells
- Authors
- A P Bouças (Author) - Universidade Federal do Rio Grande do Sul, BrazilL A Brondani (Author) - Universidade Federal do Rio Grande do Sul, BrazilB M Souza (Author) - Universidade Federal do Rio Grande do Sul, BrazilN E Lemos (Author) - Universidade Federal do Rio Grande do Sul, BrazilF S De Oliveira (Author) - Universidade Federal do Rio Grande do Sul, BrazilL H Canani (Author) - Universidade Federal do Rio Grande do Sul, BrazilD Crispim (Author) - Universidade Federal do Rio Grande do Sul, Brazil
- Publication details
- PLoS One, Vol.8(12), e83451
- Publisher
- Public Library of Science
- Date published
- 2013
- DOI
- 10.1371/journal.pone.0083451
- ISSN
- 1932-6203
- Copyright note
- Copyright © 2013 Bouças et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99450788802621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
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