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Published VersionCC BY V4.0, Open Access
Journal article
Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias
PLoS One, Vol.11(5), pp.1-20
2016
PMCID: PMC4865047
PMID: 27171035
Abstract
Background: Dystonia, a debilitating movement disorder characterized by abnormal fixed positions and/or twisting postures, is associated with dysfunction of motor control networks. While gross brain lesions can produce secondary dystonias, advanced neuroimaging techniques have been required to identify network abnormalities in primary dystonias. Prior neuroimaging studies have provided valuable insights into the pathophysiology of dystonia, but few directly assessed the gross volume of motor control regions, and to our knowledge, none identified abnormalities common to multiple types of idiopathic focal dystonia. Methods: We used two gross volumetric segmentation techniques and one voxelwise volumetric technique (voxel based morphometry, VBM) to compare regional volume between matched healthy controls and patients with idiopathic primary focal dystonia (cervical, n = 17, laryngeal, n = 7). We used (1) automated gross volume measures of eight motor control regions using the FreeSurfer analysis package; (2) blinded, anatomist-supervised manual segmentation of the whole thalamus (also gross volume); and (3) voxel based morphometry, which measures local T1-weighted signal intensity and estimates gray matter density or volume at the level of single voxels, for both whole-brain and thalamus. Results: Using both automated and manual gross volumetry, we found a significant volume decrease only in the thalamus in two focal dystonias. Decreases in whole-thalamic volume were independent of head and brain size, laterality of symptoms, and duration. VBM measures did not differ between dystonia and control groups in any motor control region. Conclusions: Reduced thalamic gross volume, detected in two independent analyses, suggests a common anatomical abnormality in cervical dystonia and spasmodic dysphonia. Defining the structural underpinnings of dystonia may require such complementary approaches.
Details
- Title
- Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias
- Authors
- Jeff L Waugh (Author) - Massachusetts General HospitalJohn K Kuster (Author) - Massachusetts General HospitalJacob M Levenstein (Author) - Massachusetts General HospitalNikos Makris (Author) - Massachusetts General HospitalTrisha J Multhaupt-Buell (Author) - Massachusetts General HospitalLewis R Sudarsky (Author) - Harvard Medical SchoolHans C R Breiter (Author) - Massachusetts General HospitalNutan Sharma (Author) - Massachusetts General HospitalAnne J Blood (Author) - Massachusetts General Hospital
- Publication details
- PLoS One, Vol.11(5), pp.1-20
- Publisher
- Public Library of Science
- Date published
- 2016
- DOI
- 10.1371/journal.pone.0155302.
- ISSN
- 1932-6203
- PMID
- 27171035; PMC4865047
- Copyright note
- © 2016 Waugh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99639278602621
- Output Type
- Journal article
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- Neurosciences
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