Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study

Danny R Youlden; Peter D Baade; H Peter Soyer; Philippa H Youl; Michael G Kimlin; Joanne F Aitken; Adele C Green; Kiarash Khosrotehrani

doi:10.1016/j.jid.2016.03.014

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Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study

Journal article

Open access

Peer reviewed

Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study

Danny R Youlden, Peter D Baade, H Peter Soyer, Philippa H Youl, Michael G Kimlin, Joanne F Aitken, Adele C Green and Kiarash Khosrotehrani

Journal of Investigative Dermatology, Vol.136(11), pp.2270-2276

2016

DOI: https://doi.org/10.1016/j.jid.2016.03.014

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Abstract

The prognosis of melanoma patients who are diagnosed with multiple primary lesions remains controversial. We used a large, population-based cohort to re-examine this issue, applying a delayed entry methodology to avoid survival bias. Of 32,238 eligible patients diagnosed between 1995 and 2008, 29,908 (93%) had a single invasive melanoma, 2,075 (6%) had two and 255 (1%) had three. Allowing for differences in entry time, 10-year cause-specific survival for these three groups was 89% (95% CI = 88%-90%), 83% (95% CI = 80%-86%) and 67% (95% CI = 54%-81%), respectively. After adjustment for key prognostic factors, the hazard ratio (HR) of death within 10 years from melanoma was two times higher for those with two melanomas (HR = 2.01, 95% CI = 1.57-2.59; p<0.001) and nearly three times higher when three melanomas were diagnosed (HR = 2.91, 95% CI = 1.64-5.18; p<0.001) compared to people with a single melanoma. Melanoma-specific mortality remained elevated after adjusting for maximum thickness or ulceration of any melanoma regardless of the index tumor. After appropriately accounting for the interval between diagnosis of the first and subsequent melanomas, patients with multiple invasive melanomas have significantly poorer survival than patients with a single invasive melanoma.

Details

Title: Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study
Authors: Danny R Youlden (Author) - Cancer Council Queensland
Peter D Baade (Author) - Griffith University
H Peter Soyer (Author) - University of Queensland
Philippa H Youl (Author) - Queensland University of Technology
Michael G Kimlin (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Joanne F Aitken (Author) - Queensland University of Technology
Adele C Green (Author) - University of Manchester, United Kingdom
Kiarash Khosrotehrani (Author) - University of Queensland
Publication details: Journal of Investigative Dermatology, Vol.136(11), pp.2270-2276
Publisher: Nature Publishing Group
Date published: 2016
DOI: 10.1016/j.jid.2016.03.014
ISSN: 0022-202X
Copyright note: Copyright © 2016 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from http://dx.doi.org/10.1016/j.jid.2016.03.014
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99449246402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Dermatology

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Source: InCites