Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs

U Drescher; J Koschate; L Thieschafer; Stefan Schneider; U Hoffmann

doi:10.1007/s00421-018-3916-x

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Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs

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Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs

U Drescher, J Koschate, L Thieschafer, Stefan Schneider and U Hoffmann

European Journal of Applied Physiology, Vol.118(9), pp.1845-1856

2018

DOI: https://doi.org/10.1007/s00421-018-3916-x

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Abstract

dynamic moderate exercise

physiological modeling

re-analysis

venous transit time

PURPOSE: The aim of the study was to test whether or not the arteriovenous oxygen concentration difference (avDO2) kinetics at the pulmonary (avDO2pulm) and muscle (avDO2musc) levels is significantly different during dynamic exercise. METHODS: A re-analysis involving six publications dealing with kinetic analysis was utilized with an overall sample size of 69 participants. All studies comprised an identical pseudorandom binary sequence work rate (WR) protocol-WR changes between 30 and 80 W-to analyze the kinetic responses of pulmonary ([Formula: see text]) and muscle ([Formula: see text]) oxygen uptake kinetics as well as those of avDO2pulm and avDO2musc. RESULTS: A significant difference between [Formula: see text] (0.395 +/- 0.079) and [Formula: see text] kinetics (0.330 +/- 0.078) was observed (p < 0.001), where the variables showed a significant relationship (rSP = 0.744, p < 0.001). There were no significant differences between avDO2musc (0.446 +/- 0.077) and avDO2pulm kinetics (0.451 +/- 0.075), which are highly correlated (r = 0.929, p < 0.001). CONCLUSION: It is suggested that neither avDO2pulm nor avDO2musc kinetic responses seem to be responsible for the differences between estimated [Formula: see text] and measured [Formula: see text] kinetics. Obviously, the conflation of avDO2 and perfusion ([Formula: see text] ) at different points in time and at different physiological levels drive potential differences in [Formula: see text] and [Formula: see text] kinetics. Therefore, [Formula: see text] should, in general, be considered whenever oxygen uptake kinetics are analyzed or discussed.

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Title: Temporal dissociation between muscle and pulmonary oxygen uptake kinetics: influences of perfusion dynamics and arteriovenous oxygen concentration differences in muscles and lungs
Authors: U Drescher (Author) - German Sport University Cologne, Germany
J Koschate (Author) - German Sport University Cologne, Germany
L Thieschafer (Author) - German Sport University Cologne, Germany
Stefan Schneider (Author) - University of the Sunshine Coast
U Hoffmann (Author) - German Sport University Cologne
Publication details: European Journal of Applied Physiology, Vol.118(9), pp.1845-1856
Publisher: Springer
Date published: 2018
DOI: 10.1007/s00421-018-3916-x
ISSN: 1439-6319
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99451364002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Physiology; Sport Sciences