Journal article
Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women
European Journal of Applied Physiology, Vol.121(9), pp.2607-2620
2021
PMID: 34106325
Abstract
Purpose:
To examine the temporal changes in blood oxidative stress biomarkers in recreationally-trained women that were naturally-cycling (WomenNC) or using oral contraceptives (WomenOC) across one month.
Methods:
Blood samples were acquired at three timepoints of the menstrual cycle (1: early-follicular, 2: late-follicular and 3: mid-luteal) and oral contraceptive packet (1: InactiveOC, 2: Mid-activeOC and 3: Late-activeOC) for determination of estradiol, progesterone, oxidative stress, C-reactive protein (CRP) and other cardiometabolic biomarkers in plasma and serum.
Results:
There was a Group by Time effect on estradiol (p < 0.001, partial η2 = 0.64) and progesterone (p < 0.001, partial η2 = 0.77). Malondialdehyde, lipid hydroperoxides and CRP concentrations were higher in WomenOC during Late-activeOC compared to InactiveOC (+ 96%, + 23% and + 104%, respectively, p < 0.05). However, there were no changes in these biomarkers across the menstrual cycle in WomenNC (p > 0.05). At all timepoints (i.e., 1, 2 and 3), WomenOC had elevated lipid hydroperoxides (+ 28, + 48% and + 50%) and CRP (+ 71%, + 117% and + 130%) compared to WomenNC (p < 0.05, partial η2 > 0.25). There was no Group by Time effect on non-enzymatic antioxidants or glutathione peroxidase; however, glutathione peroxidase was lower in WomenOC, i.e., main effect of group (p < 0.05, partial η2 > 0.20).
Conclusion:
These findings demonstrate that WomenOC not only have higher oxidative stress and CRP than WomenNC, but also a transient increase across one month of habitual oral contraceptive use. Since changes in oxidative stress and CRP often relate to training stress and recovery, these outcomes may have implications to workload monitoring practices in female athletes.
Details
- Title
- Temporal changes in blood oxidative stress biomarkers across the menstrual cycle and with oral contraceptive use in active women
- Authors
- Karlee M. Quinn (Corresponding Author) - Griffith UniversityAmanda J. Cox (Author) - Griffith UniversityLlion Roberts (Author) - Griffith UniversityEvan N. Pennell (Author) - Griffith UniversityDaniel R. McKeating (Author) - Griffith UniversityJoshua J. Fisher (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith UniversityClare Minahan (Author) - Griffith University
- Publication details
- European Journal of Applied Physiology, Vol.121(9), pp.2607-2620
- Publisher
- Springer
- DOI
- 10.1007/s00421-021-04734-0
- ISSN
- 1439-6327
- PMID
- 34106325
- Grant note
- Sport Performance Innovation and Knowledge Excellence unit, Queensland Academy of Sport
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685198302621
- Output Type
- Journal article
Metrics
7 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Physiology
- Sport Sciences
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites