Taxonomic and Metabolite Diversity of Actinomycetes Associated with Three Australian Ascidians

Larissa Buedenbender; Anthony R Carroll; Merrick Ekins; D Ipek Kurtboke

doi:10.3390/d9040053

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Taxonomic and Metabolite Diversity of Actinomycetes Associated with Three Australian Ascidians

Journal article

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Taxonomic and Metabolite Diversity of Actinomycetes Associated with Three Australian Ascidians

Larissa Buedenbender, Anthony R Carroll, Merrick Ekins and D Ipek Kurtboke

Diversity, Vol.9(4), 53

2017

DOI: https://doi.org/10.3390/d9040053

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Abstract

Actinobacteria

actinomycetes

Actinomycetales

marine microbial diversity

ascidian-associated actinomycetes

secondary metabolites

Actinomycetes are known to be the most prolific producers of biologically active metabolites. Here, we investigated the host species-specificity and the related secondary metabolites of actinomycetes that are associated with three different Australian ascidians, namely Symplegma rubra, Aplidium solidum, and Polyclinum vasculosum. Results indicated that while isolates from the genera Streptomyces and Micromonospora were highly diverse in the ascidian samples, only two culturable actinomycete Operational Taxonomic Units (OTUs) overlapped between all of the ascidians, pointing to some degree of host species-specificity of the isolates and selective acquisition of microbial associates by the host from the surrounding environment. LC-MS/MS profiling of extracts obtained from the ascidians and their actinomycete associates revealed many overlapping ions between hosts and actinomycetes, indicating that these compounds were likely to be synthesised by the microbial associates. Laboratory cultures of the actinomycetes displayed even more diverse metabolomes than those of their ascidian hosts; thus, making ascidian-associated actinomycetes an excellent target for natural product drug discovery and biotechnology.

Details

Title: Taxonomic and Metabolite Diversity of Actinomycetes Associated with Three Australian Ascidians
Authors: Larissa Buedenbender (Author) - Griffith University
Anthony R Carroll (Author) - Griffith University
Merrick Ekins (Author) - Queensland Museum
D Ipek Kurtboke (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Diversity, Vol.9(4), 53; 18
Publisher: MDPI AG
Date published: 2017
DOI: 10.3390/d9040053
ISSN: 1424-2818
Copyright note: Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering
Language: English
Record Identifier: 99450512402621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Biodiversity Conservation; Ecology

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