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Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury6.45 MB
Published VersionCC BY V4.0, Open Access
Journal article
Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury
European Journal of Nuclear Medicine and Molecular Imaging, Vol.46(5), pp.1139-1151
2019
PMID: 30617964
Abstract
PURPOSE:
Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have emerged as independent risk factors for an earlier onset of Alzheimer's disease (AD), although the pathophysiology underlying this risk is unclear. Postmortem studies have revealed extensive cerebral accumulation of tau following multiple and single TBI incidents. We hypothesized that a history of TBI and/or PTSD may induce an AD-like pattern of tau accumulation in the brain of nondemented war veterans.
METHODS:
Vietnam War veterans (mean age 71.4 years) with a history of war-related TBI and/or PTSD underwent [18F]AV145 PET as part of the US Department of Defense Alzheimer's Disease Neuroimaging Initiative. Subjects were classified into the following four groups: healthy controls (n = 21), TBI (n = 10), PTSD (n = 32), and TBI+PTSD (n = 17). [18F]AV1451 reference tissue-normalized standardized uptake value (SUVr) maps, scaled to the cerebellar grey matter, were tested for differences in tau accumulation between groups using voxel-wise and region of interest approaches, and the SUVr results were correlated with neuropsychological test scores.
RESULTS:
Compared to healthy controls, all groups showed widespread tau accumulation in neocortical regions overlapping with typical and atypical patterns of AD-like tau distribution. The TBI group showed higher tau accumulation than the other clinical groups. The extent of tauopathy was positively correlated with the neuropsychological deficit scores in the TBI+PTSD and PTSD groups.
CONCLUSION:
A history of TBI and/or PTSD may manifest in neurocognitive deficits in association with increased tau deposition in the brain of nondemented war veterans decades after their trauma. Further investigation is required to establish the burden of increased risk of dementia imparted by earlier TBI and/or PTSD.
Details
- Title
- Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury
- Authors
- Abdalla Z Mohamed (Author) - The University of QueenslandPaul Cumming (Author) - Queensland University of TechnologyJürgen Götz (Author) - The University of QueenslandFatima A Nasrallah (Corresponding Author) - The University of Queensland
- Publication details
- European Journal of Nuclear Medicine and Molecular Imaging, Vol.46(5), pp.1139-1151
- Publisher
- Springer
- Date published
- 2019
- DOI
- 10.1007/s00259-018-4241-7
- ISSN
- 1619-7089; 1619-7070
- PMID
- 30617964
- Copyright note
- This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99522405102621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging
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