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Tattoo removal with ingenol mebutate
Journal article   Open access   Peer reviewed

Tattoo removal with ingenol mebutate

Sarah-Jane Cozzi, Thuy T Le, Steven Ogbourne, Cini James and Andreas Suhrbier
Clinical, Cosmetic and Investigational Dermatology, Vol.2017(10), pp.205-210
2017
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https://doi.org/10.2147/CCID.S135716View
Published Version

Abstract

tattoo ingenol mebutate mouse
An increasing number of people are getting tattoos; however, many regret the decision and seek their removal. Lasers are currently the most commonly used method for tattoo removal; however, treatment can be lengthy, costly, and sometimes ineffective, especially for certain colors. Ingenol mebutate is a licensed topical treatment for actinic keratoses. Here, we demonstrate that two applications of 0.1% ingenol mebutate can efficiently and consistently remove 2-week-old tattoos from SKH/hr hairless mice. Treatment was associated with relocation of tattoo microspheres from the dermis into the posttreatment eschar. The skin lesion resolved about 20 days after treatment initiation, with some cicatrix formation evident. The implications for using ingenol mebutate for tattoo removal in humans are discussed.

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