Targeting oxidative stress in surgery: Effects of ageing and therapy

Salvatore Pepe; Jee-Yoong Leong; Juliana Van der Merwe; Silvana F. Marasco; Anthony Hadj; Robyn Lymbury; Anthony Perkins; Franklin L. Rosenfeldt

doi:10.1016/j.exger.2008.03.011

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Targeting oxidative stress in surgery: Effects of ageing and therapy

Journal article

Peer reviewed

Targeting oxidative stress in surgery: Effects of ageing and therapy

Salvatore Pepe, Jee-Yoong Leong, Juliana Van der Merwe, Silvana F. Marasco, Anthony Hadj, Robyn Lymbury, Anthony Perkins and Franklin L. Rosenfeldt

Experimental Gerontology, Vol.43(7), pp.653-657

2008

DOI: https://doi.org/10.1016/j.exger.2008.03.011

PMID: 18468827

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Abstract

Ageing

Alpha-lipoic acid

Cardiac surgery

Coenzyme Q 10

Human

Magnesium orotate

Omega-3 fatty acids

Oxidative stress

Selenium

In the current era cardiac surgeons are being called upon to operate upon older, sicker patients. The effect is to augment oxidative stress and increase the rate of post-operative complications and ultimately mortality. We have developed antioxidant-based pre-treatment regimes initially based on coenzyme Q10. A randomised trial of coenzyme Q10 in elective cardiac surgery patients demonstrated augmented plasma and cardiac mitochondrial membrane coenzyme Q10 content, improved mitochondrial respiration and increased myocardial tolerance of oxidative stress. The addition of ω-3 polyunsaturated fatty acids, alpha-lipoic acid, selenium and magnesium orotate in a second clinical trial, improved post-operative recovery with demonstrable reductions in myocardial damage, rate of atrial fibrillation and length of hospital stay. Finally we performed a pilot study of this combined metabolic therapy regimen to which we added preoperative physical exercise and mental stress reduction with indications of further improvements in post-operative recovery. We conclude that simultaneously targeting a number of key deficiencies with a metabolic formulation prior to surgery results in peri- and post-operative clinical and economic benefits.

Details

Title: Targeting oxidative stress in surgery: Effects of ageing and therapy
Authors: Salvatore Pepe (Author) - Alfred Hospital
Jee-Yoong Leong (Author) - Alfred Hospital
Juliana Van der Merwe (Author) - Alfred Hospital
Silvana F. Marasco (Author) - Alfred Hospital
Anthony Hadj (Author) - Alfred Hospital
Robyn Lymbury (Author) - Griffith University
Anthony Perkins (Author) - Griffith University
Franklin L. Rosenfeldt (Corresponding Author) - Alfred Hospital
Publication details: Experimental Gerontology, Vol.43(7), pp.653-657
Publisher: Elsevier Inc
DOI: 10.1016/j.exger.2008.03.011
ISSN: 1873-6815
PMID: 18468827
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
Language: English
Record Identifier: 99685195502621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Geriatrics & Gerontology

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