Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Nicole Flemming; Linda Gallo; Michael S Ward; Josephine M Forbes

doi:10.2174/1389450116666150727114410

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Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Journal article

Peer reviewed

Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Nicole Flemming, Linda Gallo, Michael S Ward and Josephine M Forbes

Current Drug Targets, Vol.17(12), pp.1341-1349

2016

DOI: https://doi.org/10.2174/1389450116666150727114410

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Abstract

diabetic complications

mitochondria

nephropathy

cellular energy

retinopathy

mitochondrial dysfunction

Mitochondria produce the majority of cellular energy via the “slow burn” of substrates such as glucose, free fatty acids and ketones. In diabetes, altered mitochondrial energetics and substrate utilisation may explain, in part, an organ’s susceptibility to complications. This is particularly evident at sites such as the kidney, heart, neurons and retina, which have high energy demands and oxygen consumption rates to meet functional requirements. Within this review we highlight the recent research implicating mitochondrial dysfunction, with particular focus on the contribution of mitochondrial reactive oxygen species, on the development and progression of diabetes complications. Finally, we discuss the current strategies which are being assessed to combat mitochondrial dysfunction in diabetes complications.

Details

Title: Tapping into Mitochondria to Find Novel Targets for Diabetes Complications
Authors: Nicole Flemming (Author) - University of Queensland
Linda Gallo (Author) - University of Queensland
Michael S Ward (Author) - University of Queensland
Josephine M Forbes (Corresponding Author) - University of Queensland
Publication details: Current Drug Targets, Vol.17(12), pp.1341-1349
Publisher: Bentham Science Publishers Ltd
DOI: 10.2174/1389450116666150727114410
ISSN: 1873-5592
Organisation Unit: School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
Language: English
Record Identifier: 99620506102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Pharmacology & Pharmacy

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