Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei

Danielle E Madden; Jessica R Webb; Eike J Steinig; Bart J Currie; Erin P Price; Derek S Sarovich

doi:10.1016/j.ebiom.2020.103152

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Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei

Journal article

Open access

Peer reviewed

Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei

Danielle E Madden, Jessica R Webb, Eike J Steinig, Bart J Currie, Erin P Price and Derek S Sarovich

EBioMedicine, Vol.63, pp.1-11

2021

DOI: https://doi.org/10.1016/j.ebiom.2020.103152

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Abstract

Melioidosis, Database

Next-generation sequencing

ARDaP

Comparative genomics

Antimicrobial resistance

Antimicrobial resistance (AMR) poses a major threat to human health. Whole-genome sequencing holds great potential for AMR identification; however, there remain major gaps in accurately and comprehensively detecting AMR across the spectrum of AMR-conferring determinants and pathogens.

Details

Title: Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei
Authors: Danielle E Madden (Author) - University of the Sunshine Coast
Jessica R Webb (Author) - Charles Darwin University
Eike J Steinig (Author) - James Cook University
Bart J Currie (Author) - Charles Darwin University
Erin P Price (Author) - University of the Sunshine Coast
Derek S Sarovich (Corresponding Author) - University of the Sunshine Coast
Publication details: EBioMedicine, Vol.63, pp.1-11
Publisher: Elsevier BV
Date published: 2021
DOI: 10.1016/j.ebiom.2020.103152
ISSN: 2352-3964
Data Availability: All genome sequence data examined in this study are publicly available on the NCBI GenBank or Sequence Read Archive databases (Table 1). The ARDaP code is freely available and accessible at: https://github.com/dsarov/ARDaP
Grants: The Darwin Perspective Melioidosis Study: Years 27-31, 1098337, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Improving Health Outcomes in the Tropical North: A Multidisciplinary Collaboration, 1131932, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Linking genomics of Burkholderia pseudomallei to melioidosis: diversity of clinical manifestations, changing epidemiology and microevolution in chronic carriage., 1046812, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: Advance Queensland (awards AQIRF0362018 and AQRF13016-17RD2), the Australian Government, and James Cook University.
Organisation Unit: School of Science and Engineering - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99493808902621
Output Type: Journal article

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