TTX, cations and spider venom modify avian muscle tone in vitro

Volker Herzig; Wayne C Hodgson; Edward G Rowan

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TTX, cations and spider venom modify avian muscle tone in vitro

Journal article

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Peer reviewed

TTX, cations and spider venom modify avian muscle tone in vitro

Volker Herzig, Wayne C Hodgson and Edward G Rowan

Journal of Venom Research, Vol.2, pp.1-5

2011

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Abstract

Medical Biochemistry and Metabolomics

Pharmacology and Pharmaceutical Sciences

Theraphosidae

Coremiocnemis tropix

venom

baseline muscle tension

chick biventer cervicis nerve-muscle preparation

Agents that reduce skeletal muscle tone may have a number of useful clinical applications, e.g., for muscle spasticity and other muscle disorders. Recently, we reported that the venoms of two species of Australian theraphosid (Araneae, Theraphosidae) spiders (Coremiocnemis tropix and Selenotholus foelschei) reduced the baseline tension of chick biventer cervicis nerve-muscle preparation. The purpose of this study was to determine the underlying physiology mediating the change in muscle tension, which was addressed by conducting isometric tension experiments. We found that MgCl2 (20mM), CaCl2 (20mM), tetrodotoxin (1µM) or C. tropix venom (2µl/ml) produced a similar decrease in baseline tension, whereas d-tubocurarine (100µM), gadolinium (1mM), verapamil (10mM), an increase in osmotic pressure by the addition of glucose (40mM), or the presence/absence of electrical stimulation did not produce a signifi cant change in baseline tension. We suggest that mechanosensitive or muscle TTX-sensitive sodium channels are activated during muscle stretch. This may have implications for the treatment of stretch induced muscle damage.

Details

Title: TTX, cations and spider venom modify avian muscle tone in vitro
Authors: Volker Herzig (Author) - University of Queensland
Wayne C Hodgson (Author) - Monash University
Edward G Rowan (Author) - University of Strathclyde, United Kingdom
Publication details: Journal of Venom Research, Vol.2, pp.1-5
Publisher: Library Publishing Media
Date published: 2011
Copyright note: Copyright © The Author(s): Published by Library Publishing Media. This is an open access article, published under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5). This license permits non-commercial use, distribution and reproduction of the article, provided the original work is appropriately acknowledged with correct citation details.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450964102621
Output Type: Journal article

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