TSGene: A web resource for tumor suppressor genes

Min Zhao; J Sun; Z Zhao

doi:10.1093/nar/gks937

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TSGene: A web resource for tumor suppressor genes

Journal article

Open access

Peer reviewed

TSGene: A web resource for tumor suppressor genes

Min Zhao, J Sun and Z Zhao

Nucleic Acids Research, Vol.41(D1), pp.D970-D976

2013

DOI: https://doi.org/10.1093/nar/gks937

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Abstract

cancer growth

computer interface

computer prediction

computer program

data collection method

gene identification

gene mapping

gene sequence

gene targeting

genetic database

online system

process development

Tumor suppressor genes (TSGs) are guardian genes that play important roles in controlling cell proliferation processes such as cell-cycle checkpoints and inducing apoptosis. Identification of these genes and understanding their functions are critical for further investigation of tumorigenesis. So far, many studies have identified numerous TSGs and illustrated their functions in various types of tumors or normal samples. Furthermore, accumulating evidence has shown that non-coding RNAs can act as TSGs to prevent the tumorigenesis processes. Therefore, there is a growing demand to integrate TSGs with large-scale experimental evidence (e.g. gene expression and epigenetic signatures) to provide a comprehensive resource for further investigation of TSGs and their molecular mechanisms in cancer. To achieve this goal, we first developed a comprehensive literature-based database called TSGene (tumor suppressor gene database), freely available at http://bioinfo.mc.vanderbilt.edu/TSGene/. In the current release, TSGene contains 716 human (637 protein-coding and 79 non-coding genes), 628 mouse and 567 rat TSGs curated from UniProtKB, the Tumor Associated Gene database and 5795 PubMed abstracts. Additionally, the TSGene provides detailed annotations for each TSG, such as cancer mutations, gene expressions, methylation sites, TF regulations and protein-protein interactions. © The Author(s) 2012.

Details

Title: TSGene: A web resource for tumor suppressor genes
Authors: Min Zhao (Author) - Vanderbilt University School of Medicine, United States
J Sun (Author) - Vanderbilt University School of Medicine, United States
Z Zhao (Author) - Vanderbilt University School of Medicine, United States
Publication details: Nucleic Acids Research, Vol.41(D1), pp.D970-D976
Publisher: Oxford University Press
Date published: 2013
DOI: 10.1093/nar/gks937
ISSN: 0305-1048
Copyright note: Copyright © The Author(s) 2012. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99448858002621
Output Type: Journal article

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