TRALI in 2 cases of leukemia

Yoke Lin Fung; Bronwyn Anne Williams

doi:10.1097/00043426-200606000-00014

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Journal article

Peer reviewed

TRALI in 2 cases of leukemia

Yoke Lin Fung and Bronwyn Anne Williams

Journal of Pediatric Hematology / Oncology, Vol.28(6), pp.391-394

2006

DOI: https://doi.org/10.1097/00043426-200606000-00014

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Abstract

Cardiovascular Medicine and Haematology

TRALI

leukemia

transfusion

respiratory distress

neutrophil

We describe transfusion-related acute lung injury (TRALI) in 2 acute leukemia cases to increase awareness of this under reported serious transfusion complication syndrome in multitransfused patients. There are a number of reports in multitransfused patients with nonmalignant disorders. However, reports of pediatric oncology patients are few, suggesting a lack of recognition or misdiagnosis of the syndrome. A disproportionately high number of fatalities in children is recorded in the literature. This highlights the need for increased awareness and appropriate treatment of this serious complication of transfusion. Although TRALI is initially a clinical diagnosis, the laboratory investigation is vital as it contributes to defining the pathogenesis of the syndrome and importantly facilitates the effective management of implicated donations and donors. An investigational strategy for suspected cases is presented and the results are discussed in the context of current proposed mechanisms for TRALI. As each transfused blood product is associated with a potential risk of TRALI, more frequent reports in patients receiving large volume or recurrent transfusion would be expected.

Details

Title: TRALI in 2 cases of leukemia
Authors: Yoke Lin Fung (Author) - Australian Red Cross Blood Service
Bronwyn Anne Williams (Author) - Queensland Health Pathology Service
Publication details: Journal of Pediatric Hematology / Oncology, Vol.28(6), pp.391-394
Publisher: Lippincott Williams & Wilkins
Date published: 2006
DOI: 10.1097/00043426-200606000-00014
ISSN: 1077-4114
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449159102621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Hematology; Oncology; Pediatrics

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