Journal article
T1-based sensing of mammographic density using single-sided portable NMR
Magnetic Resonance in Medicine, Vol.80(3), pp.1243-1251
2018
Abstract
Purpose: A single-sided NMR instrument was used to investigate the ability of the T 1 relaxation constant to distinguish between regions of low and high mammographic density in human breast tissue. Methods: Measurements were performed on 5 breast slices obtained from 3 women undergoing breast reduction surgery or prophylactic mastectomy. Results: T 1 values measured in regions of high mammographic density in both the full breast slices (T 1 5 170 6 30 ms) and excised regions (T 1 5 160 6 30 ms) were found to be significantly different (P < .001) from those measured in regions of low mammographic density, in which T 1 5 120 6 10 ms was observed both in full slices and excised regions. There was no statistically significant difference between the T 1 values measured in the full breast slices and those measured in the excised regions. Conclusion: The findings suggest that portable NMR may provide a low-cost means of assessing mammographic density in vivo. K E Y W O R D S breast cancer risk, longitudinal spin-relaxation time constant (T 1), mammographic density, mammography, portable single-sided NMR 1 | I NT ROD UCTI ON Mammographic density (MD), also known as breast density, refers to the degree of radio-opacity of the breast as observed on an X-ray mammogram. Mammographic density is determined by the amount of the radiodense fibroglandular tissue (FGT), as opposed to the radiolucent adipose, or fat, tissue in the breast. In addition to having important implications for the efficacy of mammographic breast cancer risk screening, 1 MD is an independent risk factor for breast cancer, with women in the highest MD quartile having 4 to 6 times the risk of developing breast cancer than those in the lowest 10%, after normalization for body mass index and age. 2,3 Although the mammogram is still the current standard for Magn. Reson. Med. 2018;80:1243–1251. wileyonlinelibrary.com/journal/mrm
Details
- Title
- T1-based sensing of mammographic density using single-sided portable NMR
- Authors
- Monique C Tourell (Author) - Queensland University of TechnologyTonima S Ali (Author) - Queensland University of TechnologyHonor J Hugo (Author) - Queensland University of TechnologyChris Pyke (Author) - Queensland University of TechnologySamuel Yang (Author) - Greenslopes Private HospitalThomas Lloyd (Author) - Princess Alexandra HospitalErik W Thompson (Author) - Queensland University of TechnologyKonstantin I Momot (Corresponding Author) - Queensland University of Technology
- Publication details
- Magnetic Resonance in Medicine, Vol.80(3), pp.1243-1251
- Publisher
- John Wiley & Sons, Inc.
- DOI
- 10.1002/mrm.27098
- ISSN
- 1522-2594
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99518707002621
- Output Type
- Journal article
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- Domestic collaboration
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- Radiology, Nuclear Medicine & Medical Imaging
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Source: InCites