Journal article
Systemic Antibody Response to Chlamydia Trachomatis Infection in Patients Either Infected or Reinfected with Different Chlamydia Serovars
Indian Journal of Medical Microbiology, Vol.35(3), pp.394-401
2017
Abstract
Introduction: Chlamydia trachomatis is the etiological agent for the most prevalent bacterial sexually transmitted infection in both developed and developing countries. The aim of present study was to characterize the antibody response between two groups of individuals, having either a single C. trachomatis infection and or repeated infections. Material and Methods: Current study consisted of two groups, one with an initial Chlamydia infection and a second with repeated infections. A titre based estimation of specific serum (IgG and IgA) levels using ELISA were performed, which further validated by western blot. In vitro neutralizing ability of each patient's serum against both homologous and heterologous strains was also determined. Results: Individuals infected with one of the C. trachomatis serovars D, E or K exhibited a strong systemic antibody response as characterized by ELISA and western blot. These individuals may have developed at least some level of protection as they only represented single infection. By comparison, individuals infected with serovar D, E or F that exhibited low systemic antibody response often presented repeated C. trachomatis infections, suggesting an association with poor immune response. An in vitro neutralizing level of 60-90% was observed in the human sera against homologous serovar D and two heterologous C. trachomatis serovars E and K, compared to <40% against heterologous serovars F. Conclusion: Individuals infected with serovars D and K showed a potential association between circulating antibody response and re-infection risk. While the patients infected with serovars E showed a disconnection between systemic antibody response and re-infection risk.
Details
- Title
- Systemic Antibody Response to Chlamydia Trachomatis Infection in Patients Either Infected or Reinfected with Different Chlamydia Serovars
- Authors
- Vivek K Gupta (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringCourtney Waugh (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringNoa Ziklo (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringWilhelmina M Huston (Author) - Queensland University of TechnologyJane S Hocking (Author) - University of MelbournePeter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Indian Journal of Medical Microbiology, Vol.35(3), pp.394-401
- Publisher
- Medknow Publications and Media Pvt. Ltd.
- Date published
- 2017
- DOI
- 10.4103/ijmm.IJMM_17_1
- ISSN
- 0255-0857
- Copyright note
- Copyright © 2017 The Authors. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451070502621
- Output Type
- Journal article
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- Immunology
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