Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study

Annie-Claude David; Geeta A. Thakur; Vivian Akerib; Jorge Armony; Isabelle Rouleau; Alain Brunet

doi:10.3390/bs2020103

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Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study

Journal article

Open access

Peer reviewed

Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study

Annie-Claude David, Geeta A. Thakur, Vivian Akerib, Jorge Armony, Isabelle Rouleau and Alain Brunet

Behavioral Sciences, Vol.2(2), pp.103-114

2012

DOI: https://doi.org/10.3390/bs2020103

PMID: 25379217

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Abstract

FKBP5

HPA-axis

glucocorticoid receptor

remission

Canadians

The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limiting the prognostic usefulness of such a finding. The present study sought to longitudinally explore this question by examining the association between four single-nucleotide polymorphisms (SNPs) in the FKBP5 gene (rs3800373, rs9470080, rs1360780, and rs9296158), the persistence of PTSD (severity and diagnostic status), and memory performance among twenty-two treatment-seekers diagnosed with acute PTSD. Results showed that the four SNPs significantly interacted with improvement in PTSD symptoms as well as PTSD diagnostic status. Individuals homozygous for the dominant allele and having experienced higher levels of peritraumatic responses subsequently showed more memory dysfunction. The results of this study suggest that SNPs in the FKBP5 gene are associated with symptom persistence and memory dysfunction in acute PTSD.

Details

Title: Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Study
Authors: Annie-Claude David - Université du Québec à Montréal
Geeta A. Thakur - Douglas Mental Health University Institute
Vivian Akerib - Douglas Mental Health University Institute
Jorge Armony - McGill University
Isabelle Rouleau - Université du Québec à Montréal
Alain Brunet (Corresponding Author) - McGill University
Publication details: Behavioral Sciences, Vol.2(2), pp.103-114
Publisher: MDPI AG
Date published: 2012
DOI: 10.3390/bs2020103
ISSN: 2076-328X
PMID: 25379217
Copyright note: © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Grant note: This work was funded by a grant from the Fonds de la recherche en santé du Québec (FRSQ) to A.B. and J.A. G.A.T. holds a doctoral award from the Canadian Institutes of Health Research (CIHR). A.B. holds a salary award from the FRSQ. J.A. holds a Canada reseach chair from the CIHR.
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 991105838802621
Output Type: Journal article

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