Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice

Jenna T Haerfield; Peter G Stanton; Kate L Loveland; Heba Zahid; Peter K Nicholls; Justine S Olcorn; Yogeshwar Makanji; Catherine Itman; Evan R Simpson; Sarah J Meachem

doi:10.1071/RD15239

Back

Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice

Journal article

Peer reviewed

Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice

Jenna T Haerfield, Peter G Stanton, Kate L Loveland, Heba Zahid, Peter K Nicholls, Justine S Olcorn, Yogeshwar Makanji, Catherine Itman, Evan R Simpson and Sarah J Meachem

Reproduction, Fertility and Development, Vol.29, pp.609-620

2017

DOI: https://doi.org/10.1071/RD15239

Files and links (1)

url

https://doi.org/10.1071/RD15239View

Published Version

Abstract

Medical and Health Sciences

Biological Sciences

Agricultural and Veterinary Sciences

FSH

cancer

testis

A dynamic partnership between follicle-stimulating hormone (FSH) and activin is required for normal Sertoli cell development and fertility. Disruptions to this partnership trigger Sertoli cells to deviate from their normal developmental pathway, as observed in inhibin α-knockout (Inha-KO) mice, which feature Sertoli cell tumours in adulthood. Here, we identified the developmental windows by which adult Sertoli cell tumourigenesis is most FSH sensitive. FSH was suppressed for 7 days in Inha-KO mice and wild-type littermates during the 1st, 2nd or 4th week after birth and culled in the 5th week to assess the effect on adult Sertoli cell development. Tumour growth was profoundly reduced in adult Inha-KO mice in response to FSH suppression during Weeks 1 and 2, but not Week 4. Proliferative Sertoli cells were markedly reduced in adult Inha-KO mice following FSH suppression during Weeks 1, 2 or 4, resulting in levels similar to those in wild-type mice, with greatest effect observed at the 2 week time point. Apoptotic Sertoli cells increased in adult Inha-KO mice after FSH suppression during Week 4. In conclusion, acute FSH suppression during the 1st or 2nd week after birth in Inha-KO mice profoundly suppresses Sertoli cell tumour progression, probably by inhibiting proliferation in the adult, with early postnatal Sertoli cells being most sensitive to FSH action.

Details

Title: Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice
Authors: Jenna T Haerfield (Author) - Monash University
Peter G Stanton (Author) - Monash University
Kate L Loveland (Author) - Monash University
Heba Zahid (Author) - Taibah University, Saudi Arabia
Peter K Nicholls (Author) - Monash University
Justine S Olcorn (Author) - Monash University
Yogeshwar Makanji (Author) - Hudson Institute of Medical Research
Catherine Itman (Author) - Monash University
Evan R Simpson (Author) - Monash University
Sarah J Meachem (Author) - Monash University
Publication details: Reproduction, Fertility and Development, Vol.29, pp.609-620
Publisher: C S I R O Publishing
Date published: 2017
DOI: 10.1071/RD15239
ISSN: 1031-3613
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449486502621
Output Type: Journal article

Metrics

4 File views/ downloads

736 Record Views

4 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Developmental Biology; Reproductive Biology; Zoology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites