Journal article
Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol.150B(3), pp.352-358
2009
Abstract
It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD (total N = 278). Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LOD-score of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2
Details
- Title
- Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
- Authors
- C M Middeldorp (Author) - VU University Amsterdam, NetherlandsP F Sullivan (Author) - University of North Carolina, United StatesN R Wray (Author) - Queensland Institute of Medical ResearchJ-J Hottenga (Author) - VU University Amsterdam, NetherlandsE J C de Geus (Author) - VU University Amsterdam, NetherlandsM van den Berg (Author) - Netherlands Scientific Organization, NetherlandsG W Montgomery (Author) - Netherlands Scientific Organization, NetherlandsW L Coventry (Author) - Queensland Institute of Medical ResearchDixie J Statham (Author) - Queensland Institute of Medical ResearchG Andrews (Author) - University of New South WalesP E Slagboom (Author) - Leiden University Medical Centre, NetherlandsD I Boomsma (Author) - VU University Amsterdam, NetherlandsN G Martin (Author) - Queensland Institute of Medical Research
- Publication details
- American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, Vol.150B(3), pp.352-358
- Publisher
- John Wiley & Sons Inc.
- Date published
- 2009
- DOI
- 10.1002/ajmg.b.30817
- ISSN
- 1552-4841
- Copyright note
- Copyright © 2009 The Authors. This is the accepted version of the following article: Middeldorp, C. M., Sullivan, P. F., Wray, N. R., Hottenga, J.-J., de Geus, E. J.C., van den Berg, M., Montgomery, G. W., Coventry, W. L., Statham, D. J., Andrews, G., Slagboom, P. E., Boomsma, D. I. and Martin, N. G. (2009), Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. Am. J. Med. Genet., 150B: 352-358. doi:10.1002/ajmg.b.30817, which has been published in final form at http://dx.doi.org/10.1002/ajmg.b.30817
- Organisation Unit
- School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99449755502621
- Output Type
- Journal article
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- Psychiatry
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