Journal article
Suboptimal glycemic control in adolescents and young adults with type 1 diabetes from 2011 to 2020 across Australia and New Zealand: Data from the Australasian Diabetes Data Network (ADDN) Registry
Pediatric Diabetes, Vol.23(6), pp.736-741
2022
PMID: 35561056
Abstract
Background: Competing challenges in adolescence and young adulthood can distract from optimal type 1 diabetes (T1D) self-management, and increase risks of premature morbidity and mortality. There are limited data mapping the glycaemic control of people with T1D in this age group, across Australasia.
Methods: Clinical data were extracted from the Australasian Diabetes Data Network, a prospective clinical diabetes registry. Inclusion criteria were individuals with T1D aged 16-25 years at their last recorded T1D healthcare visit (from 1st January 2011 to 31st December 2020), with T1D duration of at least one year. Data were stratified by two last recorded T1D healthcare visit ranges, while Generalised Estimated Equation (GEE) modelling was used to examine factors associated with HbA1c across visits during the ten year period.
Results: Data from 6329 young people (52.6% male) attending 24 diabetes centers across Australasia were included. At the last visit within the most recent five years, mean+SD age was 18.5+2.3 years, T1D duration was 8.8+4.7 years and HbA1c was 8.8±1.8% (72.2±19.9mmol/mol); only 12.3% had an HbA1c below the international target of <7.0% (53mmol/mol). Across all T1D healthcare visits, in GEE modelling, higher HbA1c was associated with female sex (B=0.20; 95% CI 0.12 to 0.29, p<0.001), longer T1D duration (B=0.04, 0.03 to 0.05, p<0.001). Lower HbA1c was associated with attendance at a paediatric T1D healthcare setting (B=-0.33, -0.45 to -0.21, p<0.001) and use of CSII vs. BD/MDI therapy (B=-0.49, -0.59 to 0.40, p<001).
Conclusions: This Australasian study demonstrates widespread and persistent sub-optimal glycaemic control in young people with T1D, highlighting the urgent need to better understand how healthcare services can support improved glycaemic control in this population. This article is protected by copyright. All rights reserved.
Details
- Title
- Suboptimal glycemic control in adolescents and young adults with type 1 diabetes from 2011 to 2020 across Australia and New Zealand: Data from the Australasian Diabetes Data Network (ADDN) Registry
- Authors
- Steven James (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Nursing, Midwifery and Paramedicine - LegacyAllison L Perry (Author) - University of Technology SydneyJ Lower (Author) - University of Newcastle AustraliaM Harris (Author) - University of Newcastle AustraliaMaria E Craig (Author) - Children's Hospital at Westmead
- Publication details
- Pediatric Diabetes, Vol.23(6), pp.736-741
- Publisher
- Wiley-Blackwell Publishing, Inc.
- Date published
- 2022
- DOI
- 10.1111/pedi.13364
- ISSN
- 1399-5448
- PMID
- 35561056
- Copyright note
- Copyright (C) 2022. This is the peer reviewed version of the following article: James, S., Perry, L., Lowe, J., Harris, M. and Craig, M.E. (2022), Suboptimal glycemic control in adolescents and young adults with type 1 diabetes from 2011 to 2020 across Australia and New Zealand: Data from the Australasian Diabetes Data Network registry. Pediatr Diabetes. Accepted Author Manuscript. https://doi.org/10.1111/pedi.13364, which has been published in final form at https://doi.org/10.1111/pedi.13364. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Organisation Unit
- School of Health - Nursing; University of the Sunshine Coast, Queensland; School of Nursing, Midwifery and Paramedicine - Legacy
- Language
- English
- Record Identifier
- 99640579002621
- Output Type
- Journal article
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