Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Danai Dima; Amirhossein Modabbernia; Efstathios Papachristou; Gaelle E Doucet; Ingrid Agartz; Moji Aghajani; Theophilus N Akudjedu; Anton Albajes-Eizagirre; Dag Alnaes; Kathryn I Alpert; Micael Andersson; Nancy C Andreasen; Ole A Andreassen; Philip Asherson; Tobias Banaschewski; Nuria Bargallo; Sarah Baumeister; Ramona Baur-Streubel; Alessandro Bertolino; Dorret I Boomsma; Aurora Bonvino; Stefan Borgwardt; Josiane Bourque; Daniel Brandeis; Alan Breier; Henry Brodaty; Rachel M Brouwer; Jan K Buitelaar; Geraldo F Busatto; Randy L Buckner; Vincent Calhoun; Erick J Canales-Rodríguez; Dara M Cannon; Xavier Caseras; Francisco X Castellanos; Simon Cervenka; Tiffany M Chaim-Avancini; Christopher R K Ching; Victoria Chubar; Vincent P Clark; Patricia Conrod; Annette Conzelmann; Benedicto Crespo-Facorro; Fabrice Crivello; Eveline A Crone; Anders M Dale; Christopher Davey; Eco J C de Geus; Lieuwe de Haan; Greig I de Zubicaray; Anouk den Braber; Erin W Dickie; Annabella Di Giorgio; Nhat Trung Doan; Erlend S Dørum; Stefan Ehrlich; Susanne Erk; Thomas Espeseth; Helena Fatouros-Bergman; Jean-Paul Fouche; Barbara Franke; Simon E Fisher; Thomas Frodl; Paola Fuentes-Claramonte; David C Glahn; Ian H Gotlib; Hans-Jörgen Grabe; Oliver Grimm; Nynke A Groenewold; Dominik Grotegerd; Oliver Gruber; Patricia Gruner; Rachel E Gur; Ruben C Gur; Ben J Harrison; Catharine A Hartman; Sean N Hatton; Andreas Heinz; Dirk J Heslenfeld; Ian B Hickie; Derrek P Hibar; Beng-Choon Ho; Pieter J Hoekstra; Sarah Hohmann; Avram J Holmes; Martine Hoogman; Norbert Hosten; Fleur M Howells; Hilleke E Hulshoff Pol; Chaim Huyser; Neda Jahanshad; Anthony James; Terry L Jernigan; Jiyang Jiang; Erik G Jönsson; John A Joska; Rene Kahn; Andrew Kalnin; Ryota Kanai; Marieke Klein; Tatyana P Klyushnik; Laura Koenders; Sanne Koops; Bernd Krämer; Jonna Kuntsi; Jim Lagopoulos; Luisa Lázaro; Irina Lebedeva; Won Hee Lee; Klaus-Peter Lesch; Christine Lochner; Marise W J Machielsen; Sophie Maingault; Nicholas G Martin; Ignacio Martínez-Zalacaín; David Mataix-Cols; Bernard Mazoyer; Colm McDonald; Brenna C McDonald; Katie L McMahon; Andrew M McIntosh; Genevieve McPhilemy; José M Menchón; Sarah E Medland; Andreas Meyer-Lindenberg; Jilly Naaijen; Pablo Najt; Tomohiro Nakao; Jan E Nordvik; Lars Nyberg; Jaap Oosterlaan; Víctor Ortiz-García de la Foz; Yannis Paloyelis; Paul Pauli; Giulio Pergola; Edith Pomarol-Clotet; Maria J Portella; Steven G Potkin; Joaquim Radua; Daniel A Rinker; Andreas Reif; Joshua L Roffman; Pedro G P Rosa; Matthew D Sacchet; Perminder S Sachdev; Raymond Salvador; Pascual Sánchez-Juan; Salvador Sarró; Theodore D Satterthwaite; Andrew J Saykin; Mauricio H Serpa; Lianne Schmaal; Knut Schnell; Gunter Schumann; Kang Sim; Jordan W Smoller; Iris Sommer; Carles Soriano-Mas; Dan J Stein; Suzanne C Swagerman; Lachlan T Strike; Christian K Tamnes; Henk S Temmingh; Sophia I Thomopoulos; Alexander S Tomyshev; Diana Tordesillas-Gutiérrez; Julian N Trollor; Jessica A Turner; Anne Uhlmann; Odile A van den Heuvel; Dennis van den Meer; Nic J A van der Wee; Neeltje E M van Haren; Dennis Van't Ent; Theo G M van Erp; Ilya M Veer; Dick J Veltman; Aristotle Voineskos; Henry Völzke; Esther Walton; Henrik Walter; Lei Wang; Yang Wang; Thomas H Wassink; Bernd Weber; Wei Wen; John D West; Lars T Westlye; Heather Whalley; Lara M Wierenga; Steven C R Williams; Katharina Wittfeld; Daniel H Wolf; Amanda Worker; Margaret J Wright; Kun Yang; Yulyia Yoncheva; Marcus V Zanetti; Georg C Ziegler; Sophia Frangou; Paul M Thompson

doi:10.1002/hbm.25320

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Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Journal article

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Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn I Alpert, …

Human Brain Mapping, Vol.43(1), pp.452-469

2022

DOI: https://doi.org/10.1002/hbm.25320

PMCID: PMC8675429

PMID: 33570244

Appears in Thompson Institute Research Collection

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Abstract

ENIGMA

longitudinal trajectories

brain morphometry

multisite

Other Collaborations

Thompson Institute Special Collection

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.

Details

Title: Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years
Authors: Danai Dima (Corresponding Author) - University of London
Amirhossein Modabbernia (Author) - Icahn School of Medicine at Mount Sinai
Efstathios Papachristou (Author) - University College London
Gaelle E Doucet (Author) - Icahn School of Medicine at Mount Sinai
Ingrid Agartz (Author) - University of Oslo
Moji Aghajani (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Theophilus N Akudjedu (Author) - Ollscoil na Gaillimhe – University of Galway
Anton Albajes-Eizagirre (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dag Alnaes (Author) - University of Oslo
Kathryn I Alpert (Author) - Northwestern University
Micael Andersson (Author) - Umeå University
Nancy C Andreasen (Author) - University of Iowa
Ole A Andreassen (Author) - University of Oslo
Philip Asherson (Author) - King's College London
Tobias Banaschewski (Author) - Heidelberg University
Nuria Bargallo (Author) - Hospital Clínic de Barcelona
Sarah Baumeister (Author) - Heidelberg University
Ramona Baur-Streubel (Author) - University of Würzburg
Alessandro Bertolino (Author) - University of Bari Aldo Moro
Dorret I Boomsma (Author) - VU University Amsterdam
Aurora Bonvino (Author) - University of Bari Aldo Moro
Stefan Borgwardt (Author) - University of Basel
Josiane Bourque (Author) - University of Pennsylvania
Daniel Brandeis (Author) - Heidelberg University
Alan Breier (Author) - Indiana University School of Medicine - Lafayette
Henry Brodaty (Author) - University of Zurich
Rachel M Brouwer (Author) - Utrecht University
Jan K Buitelaar (Author) - Radboud University Medical Center
Geraldo F Busatto (Author) - University of Sao Paulo
Randy L Buckner (Author) - Massachusetts General Hospital
Vincent Calhoun (Author) - Georgia Institute of Technology
Erick J Canales-Rodríguez (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dara M Cannon (Author) - Ollscoil na Gaillimhe – University of Galway
Xavier Caseras (Author) - Cardiff University
Francisco X Castellanos (Author) - New York University School of Medicine
Simon Cervenka (Author) - Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden
Tiffany M Chaim-Avancini (Author) - University of Sao Paulo
Christopher R K Ching (Author) - University of Southern California
Victoria Chubar (Author) - KU Leuven
Vincent P Clark (Author) - University of New Mexico
Patricia Conrod (Author) - Centre Hospitalier Universitaire Sainte-Justine
Annette Conzelmann (Author) - University of Tübingen
Benedicto Crespo-Facorro (Author) - HU Virgen del Rocio, IBiS, University of Sevilla, Sevilla, Spain
Fabrice Crivello (Author) - Institut des Maladies Neurodégénératives
Eveline A Crone (Author) - Leiden University
Anders M Dale (Author) - University of California San Diego
Christopher Davey (Author) - The University of Melbourne
Eco J C de Geus (Author) - VU University Amsterdam
Lieuwe de Haan (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Greig I de Zubicaray (Author) - Queensland University of Technology
Anouk den Braber (Author) - VU University Amsterdam
Erin W Dickie (Author) - University of Toronto
Annabella Di Giorgio (Author) - Casa Sollievo della Sofferenza
Nhat Trung Doan (Author) - University of Oslo
Erlend S Dørum (Author) - Sunnaas Rehabilitation Hospital HT, Nesodden, Norway
Stefan Ehrlich (Author) - University Hospital Carl Gustav Carus
Susanne Erk (Author) - Charité - Universitätsmedizin Berlin
Thomas Espeseth (Author) - Bjørknes College, Oslo, Norway
Helena Fatouros-Bergman (Author) - Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden
Jean-Paul Fouche (Author) - University of Cape Town
Barbara Franke (Author) - Radboud University Nijmegen
Simon E Fisher (Author) - Max Planck Institute for Psycholinguistics
Thomas Frodl (Author) - National Institute of Mental Health
Paola Fuentes-Claramonte (Author) - Centro de Investigación Biomédica en Red de Salud Mental
David C Glahn (Author) - Boston Children's Hospital
Ian H Gotlib (Author) - Stanford University
Hans-Jörgen Grabe (Author) - Universität Greifswald
Oliver Grimm (Author) - Goethe University Frankfurt
Nynke A Groenewold (Author) - University Medical Center Groningen
Dominik Grotegerd (Author) - University of Münster
Oliver Gruber (Author) - University Hospital Heidelberg
Patricia Gruner (Author) - Yale University
Rachel E Gur (Author) - University of Pennsylvania
Ruben C Gur (Author) - University of Pennsylvania
Ben J Harrison (Author) - The University of Melbourne
Catharine A Hartman (Author) - University of Groningen
Sean N Hatton (Author) - University of California San Diego
Andreas Heinz (Author) - Charité
Dirk J Heslenfeld (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Ian B Hickie (Author) - The University of Sydney
Derrek P Hibar (Author) - Personalized Healthcare, Genentech, Inc, South San Francisco, California, USA
Beng-Choon Ho (Author) - University of Iowa
Pieter J Hoekstra (Author) - University of Groningen
Sarah Hohmann (Author) - Heidelberg University
Avram J Holmes (Author) - Yale University
Martine Hoogman (Author) - Radboud University Nijmegen
Norbert Hosten (Author) - Universität Greifswald
Fleur M Howells (Author) - University of Cape Town
Hilleke E Hulshoff Pol (Author) - Utrecht University
Chaim Huyser (Author) - De Bascule
Neda Jahanshad (Author) - University of Southern California
Anthony James (Author) - Warneford Hospital
Terry L Jernigan (Author) - University of California San Diego
Jiyang Jiang (Author) - UNSW Australia
Erik G Jönsson (Author) - University of Oslo
John A Joska (Author) - University of Cape Town
Rene Kahn (Author) - Icahn School of Medicine at Mount Sinai
Andrew Kalnin (Author) - The Ohio State University
Ryota Kanai (Author) - Department of Neuroinformatics, Araya, Inc, Tokyo, Japan
Marieke Klein (Author) - Utrecht University
Tatyana P Klyushnik (Author) - Mental Health Research Center, Russian Academy of Medical Sciences, Moskva, Russia
Laura Koenders (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Sanne Koops (Author) - University Medical Center Utrecht
Bernd Krämer (Author) - University Hospital Heidelberg
Jonna Kuntsi (Author) - King's College London
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Luisa Lázaro (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Irina Lebedeva (Author) - Mental Health Research Center of Russian Academy of Medical Sciences
Won Hee Lee (Author) - Icahn School of Medicine at Mount Sinai
Klaus-Peter Lesch (Author) - Department of Psychiatry, Psychosomatics and Psychotherapy, Julius-Maximilians Universität Würzburg, Wurzburg, Germany
Christine Lochner (Author) - Stellenbosch University
Marise W J Machielsen (Author) - Amsterdam UMC Location University of Amsterdam
Sophie Maingault (Author) - Université de Bordeaux
Nicholas G Martin (Author) - QIMR Berghofer Medical Research Institute
Ignacio Martínez-Zalacaín (Author) - Bellvitge University Hospital
David Mataix-Cols (Author) - Karolinska Institutet
Bernard Mazoyer (Author) - Université de Bordeaux
Colm McDonald (Author) - Ollscoil na Gaillimhe – University of Galway
Brenna C McDonald (Author) - Indiana University
Katie L McMahon (Author) - Queensland University of Technology
Andrew M McIntosh (Author) - University of Edinburgh
Genevieve McPhilemy (Author) - Ollscoil na Gaillimhe – University of Galway
José M Menchón (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Sarah E Medland (Author) - QIMR Berghofer Medical Research Institute
Andreas Meyer-Lindenberg (Author) - Heidelberg University
Jilly Naaijen (Author) - Radboud University Medical Center
Pablo Najt (Author) - National University of Ireland
Tomohiro Nakao (Author) - Kyushu University
Jan E Nordvik (Author) - CatoSenteret Rehabilitation Hospital, Son, Norway
Lars Nyberg (Author) - Umeå University
Jaap Oosterlaan (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Víctor Ortiz-García de la Foz (Author) - Instituto de Salud Carlos III, Madrid, Spain
Yannis Paloyelis (Author) - King's College London
Paul Pauli (Author) - University of Würzburg
Giulio Pergola (Author) - University of Bari Aldo Moro
Edith Pomarol-Clotet (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Maria J Portella (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Steven G Potkin (Author) - University of California, Irvine
Joaquim Radua (Author) - Karolinska Institutet
Daniel A Rinker (Author) - University of Oslo
Andreas Reif (Author) - University Hospital Frankfurt
Joshua L Roffman (Author) - Harvard Medical School
Pedro G P Rosa (Author) - University of Sao Paulo
Matthew D Sacchet (Author) - Harvard Medical School
Perminder S Sachdev (Author) - UNSW Australia
Raymond Salvador (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Pascual Sánchez-Juan (Author) - Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Salvador Sarró (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Theodore D Satterthwaite (Author) - University of Pennsylvania
Andrew J Saykin (Author) - Indiana University
Mauricio H Serpa (Author) - University of Sao Paulo
Lianne Schmaal (Author) - The University of Melbourne
Knut Schnell (Author) - University of Göttingen
Gunter Schumann (Author) - King's College London
Kang Sim (Author) - Institute of Mental Health
Jordan W Smoller (Author) - Massachusetts General Hospital
Iris Sommer (Author) - University Medical Center Groningen
Carles Soriano-Mas (Author) - Centro de Investigación Biomédica en Red de Salud Mental
Dan J Stein (Author) - University of Cape Town
Suzanne C Swagerman (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Lachlan T Strike (Author) - The University of Queensland
Christian K Tamnes (Author) - University of Oslo
Henk S Temmingh (Author) - University of Cape Town
Sophia I Thomopoulos (Author) - University of Southern California
Alexander S Tomyshev (Author) - Mental Health Research Center of Russian Academy of Medical Sciences
Diana Tordesillas-Gutiérrez (Author) - Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain
Julian N Trollor (Author) - UNSW Australia
Jessica A Turner (Author) - Georgia State University
Anne Uhlmann (Author) - University of Cape Town
Odile A van den Heuvel (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
Dennis van den Meer (Author) - Maastricht University Medical Centre
Nic J A van der Wee (Author) - Leiden University Medical Center
Neeltje E M van Haren (Author) - Erasmus University Medical Center
Dennis Van't Ent (Author) - Vrije Universiteit Brussel
Theo G M van Erp (Author) - Universität Greifswald
Ilya M Veer (Author) - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Dick J Veltman (Author) - Amsterdam UMC Location Vrije Universiteit Amsterdam
Aristotle Voineskos (Author) - University of Toronto
Henry Völzke (Author) - Universität Greifswald
Esther Walton (Author) - University of Bath
Henrik Walter (Author) - Charité
Lei Wang (Author) - Northwestern University
Yang Wang (Author) - Medical College of Wisconsin
Thomas H Wassink (Author) - University of Iowa
Bernd Weber (Author) - University Hospital Bonn
Wei Wen (Author) - UNSW Australia
John D West (Author) - Indiana University
Lars T Westlye (Author) - University of Oslo
Heather Whalley (Author) - University of Edinburgh
Lara M Wierenga (Author) - Leiden University
Steven C R Williams (Author) - King's College London
Katharina Wittfeld (Author) - Universität Greifswald
Daniel H Wolf (Author) - University of Pennsylvania
Amanda Worker (Author) - King's College London
Margaret J Wright (Author) - The University of Queensland
Kun Yang (Author) - Florida State University
Yulyia Yoncheva (Author) - NYU Langone Health
Marcus V Zanetti (Author) - University of Sao Paulo
Georg C Ziegler (Author) - University of Würzburg
Sophia Frangou (Corresponding Author) - Icahn School of Medicine at Mount Sinai
Paul M Thompson (Author) - University of Southern California
Publication details: Human Brain Mapping, Vol.43(1), pp.452-469
Publisher: John Wiley & Sons, Inc.
Date published: 2022
DOI: 10.1002/hbm.25320
ISSN: 1097-0193
PMID: 33570244; PMC8675429
Copyright note: © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99511307002621
Output Type: Journal article

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